Development of novel triazolo-thiadiazoles from heterogeneous "green" catalysis as protein tyrosine phosphatase 1B inhibitors

10.1038/srep14195

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Main Authors:	Baburajeev, C.P, Dhananjaya Mohan, C, Ananda, H, Rangappa, S, Fuchs, J.E, Jagadish, S, Sivaraman Siveen, K, Chinnathambi, A, Ali Alharbi, S, Zayed, M.E, Zhang, J, Li, F, Sethi, G, Girish, K.S, Bender, A, Basappa, Rangappa, K.S
Other Authors:	DEPT OF PHARMACOLOGY
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	6-(2-benzylphenyl)-3-phenyl-(1,2,4)triazolo(3)(1,3,4)thiadiazole antineoplastic agent benzofuran derivative BIRC5 protein, human caspase 3 chromone derivative cyclin D1 inhibitor of apoptosis protein nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase protein bcl 2 protein tyrosine phosphatase 1B PTPN1 protein, human sanggenone C STAT3 protein STAT3 protein, human thiadiazole derivative triazole derivative animal antagonists and inhibitors biosynthesis Carcinoma, Ehrlich Tumor Carcinoma, Hepatocellular cell motion disease model dose response drug effects female G1 phase cell cycle checkpoint Hep-G2 cell line human Liver Neoplasms metabolism molecular model mouse Neovascularization, Pathologic pathology rat Sprague Dawley rat structure activity relation synthesis tumor cell line tumor invasion umbilical vein endothelial cell Animals Antineoplastic Agents Benzofurans Caspase 3 Cell Line, Tumor Cell Movement Chromones Cyclin D1 Disease Models, Animal Dose-Response Relationship, Drug Female G1 Phase Cell Cycle Checkpoints Hep G2 Cells Human Umbilical Vein Endothelial Cells Humans Inhibitor of Apoptosis Proteins Mice Models, Molecular Neoplasm Invasiveness Poly(ADP-ribose) Polymerases Protein Tyrosine Phosphatase, Non-Receptor Type 1 Proto-Oncogene Proteins c-bcl-2 Rats Rats, Sprague-Dawley STAT3 Transcription Factor Structure-Activity Relationship Thiadiazoles Triazoles
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/175483
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1754832023-08-30T22:32:04Z Development of novel triazolo-thiadiazoles from heterogeneous "green" catalysis as protein tyrosine phosphatase 1B inhibitors Baburajeev, C.P Dhananjaya Mohan, C Ananda, H Rangappa, S Fuchs, J.E Jagadish, S Sivaraman Siveen, K Chinnathambi, A Ali Alharbi, S Zayed, M.E Zhang, J Li, F Sethi, G Girish, K.S Bender, A Basappa Rangappa, K.S DEPT OF PHARMACOLOGY CANCER SCIENCE INSTITUTE OF SINGAPORE 6-(2-benzylphenyl)-3-phenyl-(1,2,4)triazolo(3)(1,3,4)thiadiazole antineoplastic agent benzofuran derivative BIRC5 protein, human caspase 3 chromone derivative cyclin D1 inhibitor of apoptosis protein nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase protein bcl 2 protein tyrosine phosphatase 1B PTPN1 protein, human sanggenone C STAT3 protein STAT3 protein, human thiadiazole derivative triazole derivative animal antagonists and inhibitors biosynthesis Carcinoma, Ehrlich Tumor Carcinoma, Hepatocellular cell motion disease model dose response drug effects female G1 phase cell cycle checkpoint Hep-G2 cell line human Liver Neoplasms metabolism molecular model mouse Neovascularization, Pathologic pathology rat Sprague Dawley rat structure activity relation synthesis tumor cell line tumor invasion umbilical vein endothelial cell Animals Antineoplastic Agents Benzofurans Carcinoma, Ehrlich Tumor Carcinoma, Hepatocellular Caspase 3 Cell Line, Tumor Cell Movement Chromones Cyclin D1 Disease Models, Animal Dose-Response Relationship, Drug Female G1 Phase Cell Cycle Checkpoints Hep G2 Cells Human Umbilical Vein Endothelial Cells Humans Inhibitor of Apoptosis Proteins Liver Neoplasms Mice Models, Molecular Neoplasm Invasiveness Neovascularization, Pathologic Poly(ADP-ribose) Polymerases Protein Tyrosine Phosphatase, Non-Receptor Type 1 Proto-Oncogene Proteins c-bcl-2 Rats Rats, Sprague-Dawley STAT3 Transcription Factor Structure-Activity Relationship Thiadiazoles Triazoles 10.1038/srep14195 Scientific Reports 5 14195 2020-09-10T01:51:10Z 2020-09-10T01:51:10Z 2015 Article Baburajeev, C.P, Dhananjaya Mohan, C, Ananda, H, Rangappa, S, Fuchs, J.E, Jagadish, S, Sivaraman Siveen, K, Chinnathambi, A, Ali Alharbi, S, Zayed, M.E, Zhang, J, Li, F, Sethi, G, Girish, K.S, Bender, A, Basappa, Rangappa, K.S (2015). Development of novel triazolo-thiadiazoles from heterogeneous "green" catalysis as protein tyrosine phosphatase 1B inhibitors. Scientific Reports 5 : 14195. ScholarBank@NUS Repository. https://doi.org/10.1038/srep14195 20452322 https://scholarbank.nus.edu.sg/handle/10635/175483 Nature Publishing Group Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	6-(2-benzylphenyl)-3-phenyl-(1,2,4)triazolo(3)(1,3,4)thiadiazole antineoplastic agent benzofuran derivative BIRC5 protein, human caspase 3 chromone derivative cyclin D1 inhibitor of apoptosis protein nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase protein bcl 2 protein tyrosine phosphatase 1B PTPN1 protein, human sanggenone C STAT3 protein STAT3 protein, human thiadiazole derivative triazole derivative animal antagonists and inhibitors biosynthesis Carcinoma, Ehrlich Tumor Carcinoma, Hepatocellular cell motion disease model dose response drug effects female G1 phase cell cycle checkpoint Hep-G2 cell line human Liver Neoplasms metabolism molecular model mouse Neovascularization, Pathologic pathology rat Sprague Dawley rat structure activity relation synthesis tumor cell line tumor invasion umbilical vein endothelial cell Animals Antineoplastic Agents Benzofurans Carcinoma, Ehrlich Tumor Carcinoma, Hepatocellular Caspase 3 Cell Line, Tumor Cell Movement Chromones Cyclin D1 Disease Models, Animal Dose-Response Relationship, Drug Female G1 Phase Cell Cycle Checkpoints Hep G2 Cells Human Umbilical Vein Endothelial Cells Humans Inhibitor of Apoptosis Proteins Liver Neoplasms Mice Models, Molecular Neoplasm Invasiveness Neovascularization, Pathologic Poly(ADP-ribose) Polymerases Protein Tyrosine Phosphatase, Non-Receptor Type 1 Proto-Oncogene Proteins c-bcl-2 Rats Rats, Sprague-Dawley STAT3 Transcription Factor Structure-Activity Relationship Thiadiazoles Triazoles
spellingShingle	6-(2-benzylphenyl)-3-phenyl-(1,2,4)triazolo(3)(1,3,4)thiadiazole antineoplastic agent benzofuran derivative BIRC5 protein, human caspase 3 chromone derivative cyclin D1 inhibitor of apoptosis protein nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase protein bcl 2 protein tyrosine phosphatase 1B PTPN1 protein, human sanggenone C STAT3 protein STAT3 protein, human thiadiazole derivative triazole derivative animal antagonists and inhibitors biosynthesis Carcinoma, Ehrlich Tumor Carcinoma, Hepatocellular cell motion disease model dose response drug effects female G1 phase cell cycle checkpoint Hep-G2 cell line human Liver Neoplasms metabolism molecular model mouse Neovascularization, Pathologic pathology rat Sprague Dawley rat structure activity relation synthesis tumor cell line tumor invasion umbilical vein endothelial cell Animals Antineoplastic Agents Benzofurans Carcinoma, Ehrlich Tumor Carcinoma, Hepatocellular Caspase 3 Cell Line, Tumor Cell Movement Chromones Cyclin D1 Disease Models, Animal Dose-Response Relationship, Drug Female G1 Phase Cell Cycle Checkpoints Hep G2 Cells Human Umbilical Vein Endothelial Cells Humans Inhibitor of Apoptosis Proteins Liver Neoplasms Mice Models, Molecular Neoplasm Invasiveness Neovascularization, Pathologic Poly(ADP-ribose) Polymerases Protein Tyrosine Phosphatase, Non-Receptor Type 1 Proto-Oncogene Proteins c-bcl-2 Rats Rats, Sprague-Dawley STAT3 Transcription Factor Structure-Activity Relationship Thiadiazoles Triazoles Baburajeev, C.P Dhananjaya Mohan, C Ananda, H Rangappa, S Fuchs, J.E Jagadish, S Sivaraman Siveen, K Chinnathambi, A Ali Alharbi, S Zayed, M.E Zhang, J Li, F Sethi, G Girish, K.S Bender, A Basappa Rangappa, K.S Development of novel triazolo-thiadiazoles from heterogeneous "green" catalysis as protein tyrosine phosphatase 1B inhibitors
description	10.1038/srep14195
author2	DEPT OF PHARMACOLOGY
author_facet	DEPT OF PHARMACOLOGY Baburajeev, C.P Dhananjaya Mohan, C Ananda, H Rangappa, S Fuchs, J.E Jagadish, S Sivaraman Siveen, K Chinnathambi, A Ali Alharbi, S Zayed, M.E Zhang, J Li, F Sethi, G Girish, K.S Bender, A Basappa Rangappa, K.S
format	Article
author	Baburajeev, C.P Dhananjaya Mohan, C Ananda, H Rangappa, S Fuchs, J.E Jagadish, S Sivaraman Siveen, K Chinnathambi, A Ali Alharbi, S Zayed, M.E Zhang, J Li, F Sethi, G Girish, K.S Bender, A Basappa Rangappa, K.S
author_sort	Baburajeev, C.P
title	Development of novel triazolo-thiadiazoles from heterogeneous "green" catalysis as protein tyrosine phosphatase 1B inhibitors
title_short	Development of novel triazolo-thiadiazoles from heterogeneous "green" catalysis as protein tyrosine phosphatase 1B inhibitors
title_full	Development of novel triazolo-thiadiazoles from heterogeneous "green" catalysis as protein tyrosine phosphatase 1B inhibitors
title_fullStr	Development of novel triazolo-thiadiazoles from heterogeneous "green" catalysis as protein tyrosine phosphatase 1B inhibitors
title_full_unstemmed	Development of novel triazolo-thiadiazoles from heterogeneous "green" catalysis as protein tyrosine phosphatase 1B inhibitors
title_sort	development of novel triazolo-thiadiazoles from heterogeneous "green" catalysis as protein tyrosine phosphatase 1b inhibitors
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/175483
_version_	1778169928568799232

Development of novel triazolo-thiadiazoles from heterogeneous "green" catalysis as protein tyrosine phosphatase 1B inhibitors

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