A loss-of-function genetic screening reveals synergistic targeting of AKT/mTOR and WTN/β-catenin pathways for treatment of AML with high PRL-3 phosphatase

10.1186/s13045-018-0581-9

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Main Authors:	Zhou, J, Toh, S.H.-M, Chan, Z.-L, Quah, J.Y, Chooi, J.-Y, Tan, T.Z, Chong, P.S.Y, Zeng, Q, Chng, W.-J
Other Authors:	CANCER SCIENCE INSTITUTE OF SINGAPORE
Format:	Article
Published:	2020
Subjects:	beta catenin mammalian target of rapamycin oncoprotein PRL 3 phosphatase protein kinase B short hairpin RNA unclassified drug Wnt protein MTOR protein, human protein tyrosine phosphatase PTP4A3 protein, human target of rapamycin kinase tumor protein acute myeloid leukemia acute myeloid leukemia cell line Akt/mTOR signaling animal experiment animal model Article bone marrow cell cancer prognosis cancer survival cell assay controlled study enzyme inhibition gene library genetic screening human human cell in vitro study in vivo study mouse nonhuman protein expression protein protein interaction protein targeting upregulation Wnt beta catenin signaling Wnt signaling animal female genetics metabolism nonobese diabetic mouse procedures SCID mouse Animals beta Catenin Female Genetic Testing Humans Leukemia, Myeloid, Acute Mice Mice, Inbred NOD Mice, SCID Neoplasm Proteins Protein Tyrosine Phosphatases Proto-Oncogene Proteins c-akt TOR Serine-Threonine Kinases Wnt Signaling Pathway
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/178101
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1781012024-04-24T05:54:09Z A loss-of-function genetic screening reveals synergistic targeting of AKT/mTOR and WTN/β-catenin pathways for treatment of AML with high PRL-3 phosphatase Zhou, J Toh, S.H.-M Chan, Z.-L Quah, J.Y Chooi, J.-Y Tan, T.Z Chong, P.S.Y Zeng, Q Chng, W.-J CANCER SCIENCE INSTITUTE OF SINGAPORE BIOCHEMISTRY MEDICINE beta catenin mammalian target of rapamycin oncoprotein PRL 3 phosphatase protein kinase B short hairpin RNA unclassified drug Wnt protein beta catenin MTOR protein, human protein kinase B protein tyrosine phosphatase PTP4A3 protein, human target of rapamycin kinase tumor protein acute myeloid leukemia acute myeloid leukemia cell line Akt/mTOR signaling animal experiment animal model Article bone marrow cell cancer prognosis cancer survival cell assay controlled study enzyme inhibition gene library genetic screening human human cell in vitro study in vivo study mouse nonhuman protein expression protein protein interaction protein targeting upregulation Wnt beta catenin signaling Wnt signaling acute myeloid leukemia animal female genetic screening genetics metabolism nonobese diabetic mouse procedures SCID mouse Wnt signaling Animals beta Catenin Female Genetic Testing Humans Leukemia, Myeloid, Acute Mice Mice, Inbred NOD Mice, SCID Neoplasm Proteins Protein Tyrosine Phosphatases Proto-Oncogene Proteins c-akt TOR Serine-Threonine Kinases Wnt Signaling Pathway 10.1186/s13045-018-0581-9 Journal of Hematology and Oncology 11 1 36 2020-10-20T05:06:09Z 2020-10-20T05:06:09Z 2018 Article Zhou, J, Toh, S.H.-M, Chan, Z.-L, Quah, J.Y, Chooi, J.-Y, Tan, T.Z, Chong, P.S.Y, Zeng, Q, Chng, W.-J (2018). A loss-of-function genetic screening reveals synergistic targeting of AKT/mTOR and WTN/β-catenin pathways for treatment of AML with high PRL-3 phosphatase. Journal of Hematology and Oncology 11 (1) : 36. ScholarBank@NUS Repository. https://doi.org/10.1186/s13045-018-0581-9 17568722 https://scholarbank.nus.edu.sg/handle/10635/178101 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	beta catenin mammalian target of rapamycin oncoprotein PRL 3 phosphatase protein kinase B short hairpin RNA unclassified drug Wnt protein beta catenin MTOR protein, human protein kinase B protein tyrosine phosphatase PTP4A3 protein, human target of rapamycin kinase tumor protein acute myeloid leukemia acute myeloid leukemia cell line Akt/mTOR signaling animal experiment animal model Article bone marrow cell cancer prognosis cancer survival cell assay controlled study enzyme inhibition gene library genetic screening human human cell in vitro study in vivo study mouse nonhuman protein expression protein protein interaction protein targeting upregulation Wnt beta catenin signaling Wnt signaling acute myeloid leukemia animal female genetic screening genetics metabolism nonobese diabetic mouse procedures SCID mouse Wnt signaling Animals beta Catenin Female Genetic Testing Humans Leukemia, Myeloid, Acute Mice Mice, Inbred NOD Mice, SCID Neoplasm Proteins Protein Tyrosine Phosphatases Proto-Oncogene Proteins c-akt TOR Serine-Threonine Kinases Wnt Signaling Pathway
spellingShingle	beta catenin mammalian target of rapamycin oncoprotein PRL 3 phosphatase protein kinase B short hairpin RNA unclassified drug Wnt protein beta catenin MTOR protein, human protein kinase B protein tyrosine phosphatase PTP4A3 protein, human target of rapamycin kinase tumor protein acute myeloid leukemia acute myeloid leukemia cell line Akt/mTOR signaling animal experiment animal model Article bone marrow cell cancer prognosis cancer survival cell assay controlled study enzyme inhibition gene library genetic screening human human cell in vitro study in vivo study mouse nonhuman protein expression protein protein interaction protein targeting upregulation Wnt beta catenin signaling Wnt signaling acute myeloid leukemia animal female genetic screening genetics metabolism nonobese diabetic mouse procedures SCID mouse Wnt signaling Animals beta Catenin Female Genetic Testing Humans Leukemia, Myeloid, Acute Mice Mice, Inbred NOD Mice, SCID Neoplasm Proteins Protein Tyrosine Phosphatases Proto-Oncogene Proteins c-akt TOR Serine-Threonine Kinases Wnt Signaling Pathway Zhou, J Toh, S.H.-M Chan, Z.-L Quah, J.Y Chooi, J.-Y Tan, T.Z Chong, P.S.Y Zeng, Q Chng, W.-J A loss-of-function genetic screening reveals synergistic targeting of AKT/mTOR and WTN/β-catenin pathways for treatment of AML with high PRL-3 phosphatase
description	10.1186/s13045-018-0581-9
author2	CANCER SCIENCE INSTITUTE OF SINGAPORE
author_facet	CANCER SCIENCE INSTITUTE OF SINGAPORE Zhou, J Toh, S.H.-M Chan, Z.-L Quah, J.Y Chooi, J.-Y Tan, T.Z Chong, P.S.Y Zeng, Q Chng, W.-J
format	Article
author	Zhou, J Toh, S.H.-M Chan, Z.-L Quah, J.Y Chooi, J.-Y Tan, T.Z Chong, P.S.Y Zeng, Q Chng, W.-J
author_sort	Zhou, J
title	A loss-of-function genetic screening reveals synergistic targeting of AKT/mTOR and WTN/β-catenin pathways for treatment of AML with high PRL-3 phosphatase
title_short	A loss-of-function genetic screening reveals synergistic targeting of AKT/mTOR and WTN/β-catenin pathways for treatment of AML with high PRL-3 phosphatase
title_full	A loss-of-function genetic screening reveals synergistic targeting of AKT/mTOR and WTN/β-catenin pathways for treatment of AML with high PRL-3 phosphatase
title_fullStr	A loss-of-function genetic screening reveals synergistic targeting of AKT/mTOR and WTN/β-catenin pathways for treatment of AML with high PRL-3 phosphatase
title_full_unstemmed	A loss-of-function genetic screening reveals synergistic targeting of AKT/mTOR and WTN/β-catenin pathways for treatment of AML with high PRL-3 phosphatase
title_sort	loss-of-function genetic screening reveals synergistic targeting of akt/mtor and wtn/β-catenin pathways for treatment of aml with high prl-3 phosphatase
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/178101
_version_	1800914476584665088

A loss-of-function genetic screening reveals synergistic targeting of AKT/mTOR and WTN/β-catenin pathways for treatment of AML with high PRL-3 phosphatase

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