NOS2-deficient mice with hypoxic necrotizing lung lesions predict outcomes of tuberculosis chemotherapy in humans

• Main Authors: Gengenbacher, M, Duque-Correa, M.A, Kaiser, P, Schuerer, S, Lazar, D, Zedler, U, Reece, S.T, Nayyar, A, Cole, S.T, Makarov, V, Barry, C.E, Dartois, V, Kaufmann, S.H.E
• Other Authors: MEDICINE
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: inducible nitric oxide synthase; isoniazid; Nos2 protein, mouse; rifampicin; rifapentine; tuberculostatic agent; analogs and derivatives; animal; deficiency; disease model; fibrosis; foam cell; genetics; human; hypoxia; immunology; knockout mouse; lung tuberculosis; metabolism; mouse; necrosis; pathology; treatment outcome; Animals; Antitubercular Agents; Disease Models, Animal; Fibrosis; Foam Cells; Humans; Hypoxia; Isoniazid; Mice; Mice, Knockout; Necrosis; Nitric Oxide Synthase Type II; Rifampin; Treatment Outcome; Tuberculosis, Pulmonary
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178592
• Institution: National University of Singapore

10.1038/s41598-017-09177-2