Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis

10.1007/s00401-017-1698-6

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Main Authors:	Ditsworth, D, Maldonado, M, McAlonis-Downes, M, Sun, S, Seelman, A, Drenner, K, Arnold, E, Ling, S.-C, Pizzo, D, Ravits, J, Cleveland, D.W, Da Cruz, S
Other Authors:	PHYSIOLOGY
Format:	Article
Published:	Springer Verlag 2020
Subjects:	cre recombinase mutant protein TAR DNA binding protein DNA binding protein TDP-43 protein, human allele amyotrophic lateral sclerosis animal cell animal experiment animal model animal tissue Article astrocytosis axon controlled study disease course gene expression gene mutation gliosis human human tissue motoneuron mouse nerve cell degeneration nerve cell necrosis neuromuscular junction nonhuman priority journal adult aging animal C57BL mouse disease exacerbation disease model female genetics inflammation male metabolism middle aged motor activity mutation pathology physiology transgenic mouse very elderly young adult Adult Aged, 80 and over Aging Amyotrophic Lateral Sclerosis Animals Disease Models, Animal Disease Progression DNA-Binding Proteins Female Humans Inflammation Male Mice, Inbred C57BL Mice, Transgenic Middle Aged Motor Activity Motor Neurons Mutation Neuromuscular Junction Young Adult
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/179201
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1792012024-04-04T01:11:01Z Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis Ditsworth, D Maldonado, M McAlonis-Downes, M Sun, S Seelman, A Drenner, K Arnold, E Ling, S.-C Pizzo, D Ravits, J Cleveland, D.W Da Cruz, S PHYSIOLOGY cre recombinase mutant protein TAR DNA binding protein DNA binding protein TDP-43 protein, human allele amyotrophic lateral sclerosis animal cell animal experiment animal model animal tissue Article astrocytosis axon controlled study disease course gene expression gene mutation gliosis human human tissue motoneuron mouse nerve cell degeneration nerve cell necrosis neuromuscular junction nonhuman priority journal adult aging amyotrophic lateral sclerosis animal C57BL mouse disease exacerbation disease model female genetics inflammation male metabolism middle aged motoneuron motor activity mutation pathology physiology transgenic mouse very elderly young adult Adult Aged, 80 and over Aging Amyotrophic Lateral Sclerosis Animals Disease Models, Animal Disease Progression DNA-Binding Proteins Female Humans Inflammation Male Mice, Inbred C57BL Mice, Transgenic Middle Aged Motor Activity Motor Neurons Mutation Neuromuscular Junction Young Adult 10.1007/s00401-017-1698-6 Acta Neuropathologica 133 6 907-922 2020-10-23T02:28:45Z 2020-10-23T02:28:45Z 2017 Article Ditsworth, D, Maldonado, M, McAlonis-Downes, M, Sun, S, Seelman, A, Drenner, K, Arnold, E, Ling, S.-C, Pizzo, D, Ravits, J, Cleveland, D.W, Da Cruz, S (2017). Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis. Acta Neuropathologica 133 (6) : 907-922. ScholarBank@NUS Repository. https://doi.org/10.1007/s00401-017-1698-6 00016322 https://scholarbank.nus.edu.sg/handle/10635/179201 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Springer Verlag Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	cre recombinase mutant protein TAR DNA binding protein DNA binding protein TDP-43 protein, human allele amyotrophic lateral sclerosis animal cell animal experiment animal model animal tissue Article astrocytosis axon controlled study disease course gene expression gene mutation gliosis human human tissue motoneuron mouse nerve cell degeneration nerve cell necrosis neuromuscular junction nonhuman priority journal adult aging amyotrophic lateral sclerosis animal C57BL mouse disease exacerbation disease model female genetics inflammation male metabolism middle aged motoneuron motor activity mutation pathology physiology transgenic mouse very elderly young adult Adult Aged, 80 and over Aging Amyotrophic Lateral Sclerosis Animals Disease Models, Animal Disease Progression DNA-Binding Proteins Female Humans Inflammation Male Mice, Inbred C57BL Mice, Transgenic Middle Aged Motor Activity Motor Neurons Mutation Neuromuscular Junction Young Adult
spellingShingle	cre recombinase mutant protein TAR DNA binding protein DNA binding protein TDP-43 protein, human allele amyotrophic lateral sclerosis animal cell animal experiment animal model animal tissue Article astrocytosis axon controlled study disease course gene expression gene mutation gliosis human human tissue motoneuron mouse nerve cell degeneration nerve cell necrosis neuromuscular junction nonhuman priority journal adult aging amyotrophic lateral sclerosis animal C57BL mouse disease exacerbation disease model female genetics inflammation male metabolism middle aged motoneuron motor activity mutation pathology physiology transgenic mouse very elderly young adult Adult Aged, 80 and over Aging Amyotrophic Lateral Sclerosis Animals Disease Models, Animal Disease Progression DNA-Binding Proteins Female Humans Inflammation Male Mice, Inbred C57BL Mice, Transgenic Middle Aged Motor Activity Motor Neurons Mutation Neuromuscular Junction Young Adult Ditsworth, D Maldonado, M McAlonis-Downes, M Sun, S Seelman, A Drenner, K Arnold, E Ling, S.-C Pizzo, D Ravits, J Cleveland, D.W Da Cruz, S Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis
description	10.1007/s00401-017-1698-6
author2	PHYSIOLOGY
author_facet	PHYSIOLOGY Ditsworth, D Maldonado, M McAlonis-Downes, M Sun, S Seelman, A Drenner, K Arnold, E Ling, S.-C Pizzo, D Ravits, J Cleveland, D.W Da Cruz, S
format	Article
author	Ditsworth, D Maldonado, M McAlonis-Downes, M Sun, S Seelman, A Drenner, K Arnold, E Ling, S.-C Pizzo, D Ravits, J Cleveland, D.W Da Cruz, S
author_sort	Ditsworth, D
title	Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis
title_short	Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis
title_full	Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis
title_fullStr	Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis
title_full_unstemmed	Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis
title_sort	mutant tdp-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis
publisher	Springer Verlag
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/179201
_version_	1795374478012710912

Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis

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