Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis

Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis

10.1007/s00401-017-1698-6

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Bibliographic Details
Main Authors:	Ditsworth, D, Maldonado, M, McAlonis-Downes, M, Sun, S, Seelman, A, Drenner, K, Arnold, E, Ling, S.-C, Pizzo, D, Ravits, J, Cleveland, D.W, Da Cruz, S
Other Authors:	PHYSIOLOGY
Format:	Article
Published:	Springer Verlag 2020
Subjects:	cre recombinase mutant protein TAR DNA binding protein DNA binding protein TDP-43 protein, human allele amyotrophic lateral sclerosis animal cell animal experiment animal model animal tissue Article astrocytosis axon controlled study disease course gene expression gene mutation gliosis human human tissue motoneuron mouse nerve cell degeneration nerve cell necrosis neuromuscular junction nonhuman priority journal adult aging animal C57BL mouse disease exacerbation disease model female genetics inflammation male metabolism middle aged motor activity mutation pathology physiology transgenic mouse very elderly young adult Adult Aged, 80 and over Aging Amyotrophic Lateral Sclerosis Animals Disease Models, Animal Disease Progression DNA-Binding Proteins Female Humans Inflammation Male Mice, Inbred C57BL Mice, Transgenic Middle Aged Motor Activity Motor Neurons Mutation Neuromuscular Junction Young Adult
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/179201
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Institution:	National University of Singapore

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