EGF hijacks miR-198/FSTL1 wound-healing switch and steers a two-pronged pathway toward metastasis

• Main Authors: Sundaram, G.M, Ismail, H.M, Bashir, M, Muhuri, M, Vaz, C, Nama, S, Ow, G.S, Vladimirovna, I.A, Ramalingam, R, Burke, B, Tanavde, V, Kuznetsov, V, Birgitte Lane, E, Sampath, P
• Other Authors: DEPT OF BIOCHEMISTRY
• Format: Article
• Published: Rockefeller University Press 2020
• Subjects: actin related protein 2-3 complex; dIAPH1 protein; epidermal growth factor; follistatin; follistatin like 1; gelatinase B; microRNA; microRNA 198; mitogen activated protein kinase; unclassified drug; Wnt7a protein; follistatin related protein; Fstl1 protein, mouse; MIRN198 microRNA, human; MIRN198 microRNA, mouse; 3' untranslated region; A-253 cell line; animal experiment; animal model; Article; cancer prognosis; cancer survival; carcinogenesis; cell lysate; cell migration; cell proliferation; competitive inhibition; controlled study; down regulation; enzyme activity; enzyme phosphorylation; enzyme synthesis; extracellular matrix; FaDu cell line; fluorescence in situ hybridization; gene expression; gene repression; gene switching; gene targeting; head and neck squamous cell carcinoma; human; human cell; immunohistochemistry; immunoprecipitation; in vivo study; metastasis; molecular pathology; mouse; nonhuman; overall survival; priority journal; protein protein interaction; RNA transcription; RNA translation; SCC-12 cell line; upregulation; Western blotting; wound healing; animal; cell transformation; female; head and neck tumor; mass spectrometry; metabolism; nonobese diabetic mouse; physiology; regulator gene; squamous cell carcinoma; Animals; Blotting, Western; Carcinoma, Squamous Cell; Cell Proliferation; Cell Transformation, Neoplastic; Epidermal Growth Factor; Female; Follistatin-Related Proteins; Genes, Switch; Head and Neck Neoplasms; Immunoprecipitation; Mass Spectrometry; Mice, Inbred NOD; MicroRNAs; Wound Healing
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179257
• Institution: National University of Singapore

10.1084/jem.20170354