Complex regulation of neutrophil-derived MMP-9 secretion in central nervous system tuberculosis

• Main Authors: Ong, C.W.M, Pabisiak, P.J, Brilha, S, Singh, P, Roncaroli, F, Elkington, P.T, Friedland, J.S
• Other Authors: MEDICINE
• Format: Article
• Published: 2020
• Subjects: collagen type 4; dexamethasone; gelatinase B; immunoglobulin enhancer binding protein; leukocyte elastase; mitogen activated protein kinase; mitogen activated protein kinase p38; neutrophil collagenase; phosphatidylinositol 3 kinase; protein kinase B; protein S 100; tumor necrosis factor; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; antibody; chromone derivative; enzyme inhibitor; morpholine derivative; oncoprotein; peroxidase; Article; bacterium culture; basement membrane; blood brain barrier; brain biopsy; cell viability; central nervous system tuberculosis; collagen degradation; confocal microscopy; controlled study; enzyme linked immunosorbent assay; fluorescence activated cell sorting; gene expression; genotype; histopathology; human; human experiment; immunofluorescence microscopy; immunohistochemistry; immunopathology; macrophage; monocyte; Mycobacterium tuberculosis; neutrophil; neutrophil count; normal human; protein secretion; real time polymerase chain reaction; signal transduction; supernatant; upregulation; cell culture; dose response; drug effects; female; gene expression regulation; genetics; immunology; leukocyte; male; metabolism; pathology; physiology; secretion (process); Antibodies; Cells, Cultured; Chromones; Collagen Type IV; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gene Expression Regulation, Bacterial; Humans; Leukocytes; Male; Matrix Metalloproteinase 9; Morpholines; Neutrophils; NF-kappa B; Oncogene Protein v-akt; Peroxidase; Signal Transduction; Tuberculosis, Central Nervous System; Up-Regulation
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179530
• Institution: National University of Singapore

10.1186/s12974-017-0801-1