Valproic acid suppresses collagen by selective regulation of Smads in conjunctival fibrosis

• Main Authors: Seet, L.-F, Toh, L.Z, Finger, S.N, Chu, S.W.L, Stefanovic, B, Wong, T.T
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Springer Verlag 2020
• Subjects: alpha smooth muscle actin; beta actin; collagen type 1; messenger RNA; short hairpin RNA; Smad protein; Smad2 protein; Smad4 protein; Smad6 protein; tenascin; transforming growth factor beta2; valproic acid; enzyme inhibitor; animal cell; animal experiment; animal model; apoptosis; Article; cell differentiation; cell viability; collagen fiber; conjunctiva disease; conjunctival fibrosis; fibroblast; fibrosis; filtering operation; glaucoma; mouse; myofibroblast; nonhuman; phenotype; promoter region; protein expression; regulatory mechanism; steady state; wound healing; animal; C57BL mouse; cell culture; complication; conjunctiva; drug effects; gene expression regulation; genetics; metabolism; pathology; Animals; Cells, Cultured; Collagen Type I; Conjunctiva; Enzyme Inhibitors; Fibroblasts; Fibrosis; Gene Expression Regulation; Glaucoma; Mice; Mice, Inbred C57BL; Smad Proteins; Transforming Growth Factor beta2; Valproic Acid
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179594
• Institution: National University of Singapore

10.1007/s00109-015-1358-z