Structure of the NS2B-NS3 protease from Zika virus after self-cleavage

10.1038/ncomms13410

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Main Authors:	Phoo, W.W, Li, Y, Zhang, Z, Lee, M.Y, Loh, Y.R, Tan, Y.B, Ng, E.Y, Lescar, J, Kang, C, Luo, D
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	nonstructural protein 2B nonstructural protein 3 polyprotein protease inhibitor BPTI proteinase proteinase inhibitor structural protein unclassified drug peptide hydrolase protein binding viral protein amino acid crystal structure nuclear magnetic resonance population outbreak protein public health substrate viral disease virus Article carboxy terminal sequence comparative study controlled study enzyme active site enzyme activity enzyme assay enzyme inhibition enzyme structure molecular recognition nonhuman protein degradation protein expression protein processing Zika virus binding site chemistry human metabolism molecular model nuclear magnetic resonance spectroscopy protein conformation X ray crystallography North America South America Flavivirus Binding Sites Catalytic Domain Crystallography, X-Ray Humans Magnetic Resonance Spectroscopy Models, Molecular Peptide Hydrolases Protein Binding Protein Conformation Proteolysis Viral Nonstructural Proteins Zika Virus
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/179788
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1797882023-09-20T08:44:37Z Structure of the NS2B-NS3 protease from Zika virus after self-cleavage Phoo, W.W Li, Y Zhang, Z Lee, M.Y Loh, Y.R Tan, Y.B Ng, E.Y Lescar, J Kang, C Luo, D DUKE-NUS MEDICAL SCHOOL nonstructural protein 2B nonstructural protein 3 polyprotein protease inhibitor BPTI proteinase proteinase inhibitor structural protein unclassified drug peptide hydrolase protein binding viral protein amino acid crystal structure nuclear magnetic resonance population outbreak protein public health substrate viral disease virus Article carboxy terminal sequence comparative study controlled study crystal structure enzyme active site enzyme activity enzyme assay enzyme inhibition enzyme structure molecular recognition nonhuman nuclear magnetic resonance protein degradation protein expression protein processing Zika virus binding site chemistry human metabolism molecular model nuclear magnetic resonance spectroscopy protein conformation X ray crystallography Zika virus North America South America Flavivirus Zika virus Binding Sites Catalytic Domain Crystallography, X-Ray Humans Magnetic Resonance Spectroscopy Models, Molecular Peptide Hydrolases Protein Binding Protein Conformation Proteolysis Viral Nonstructural Proteins Zika Virus 10.1038/ncomms13410 Nature Communications 7 13410 2020-10-26T03:06:52Z 2020-10-26T03:06:52Z 2016 Article Phoo, W.W, Li, Y, Zhang, Z, Lee, M.Y, Loh, Y.R, Tan, Y.B, Ng, E.Y, Lescar, J, Kang, C, Luo, D (2016). Structure of the NS2B-NS3 protease from Zika virus after self-cleavage. Nature Communications 7 : 13410. ScholarBank@NUS Repository. https://doi.org/10.1038/ncomms13410 2041-1723 https://scholarbank.nus.edu.sg/handle/10635/179788 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Nature Publishing Group Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	nonstructural protein 2B nonstructural protein 3 polyprotein protease inhibitor BPTI proteinase proteinase inhibitor structural protein unclassified drug peptide hydrolase protein binding viral protein amino acid crystal structure nuclear magnetic resonance population outbreak protein public health substrate viral disease virus Article carboxy terminal sequence comparative study controlled study crystal structure enzyme active site enzyme activity enzyme assay enzyme inhibition enzyme structure molecular recognition nonhuman nuclear magnetic resonance protein degradation protein expression protein processing Zika virus binding site chemistry human metabolism molecular model nuclear magnetic resonance spectroscopy protein conformation X ray crystallography Zika virus North America South America Flavivirus Zika virus Binding Sites Catalytic Domain Crystallography, X-Ray Humans Magnetic Resonance Spectroscopy Models, Molecular Peptide Hydrolases Protein Binding Protein Conformation Proteolysis Viral Nonstructural Proteins Zika Virus
spellingShingle	nonstructural protein 2B nonstructural protein 3 polyprotein protease inhibitor BPTI proteinase proteinase inhibitor structural protein unclassified drug peptide hydrolase protein binding viral protein amino acid crystal structure nuclear magnetic resonance population outbreak protein public health substrate viral disease virus Article carboxy terminal sequence comparative study controlled study crystal structure enzyme active site enzyme activity enzyme assay enzyme inhibition enzyme structure molecular recognition nonhuman nuclear magnetic resonance protein degradation protein expression protein processing Zika virus binding site chemistry human metabolism molecular model nuclear magnetic resonance spectroscopy protein conformation X ray crystallography Zika virus North America South America Flavivirus Zika virus Binding Sites Catalytic Domain Crystallography, X-Ray Humans Magnetic Resonance Spectroscopy Models, Molecular Peptide Hydrolases Protein Binding Protein Conformation Proteolysis Viral Nonstructural Proteins Zika Virus Phoo, W.W Li, Y Zhang, Z Lee, M.Y Loh, Y.R Tan, Y.B Ng, E.Y Lescar, J Kang, C Luo, D Structure of the NS2B-NS3 protease from Zika virus after self-cleavage
description	10.1038/ncomms13410
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Phoo, W.W Li, Y Zhang, Z Lee, M.Y Loh, Y.R Tan, Y.B Ng, E.Y Lescar, J Kang, C Luo, D
format	Article
author	Phoo, W.W Li, Y Zhang, Z Lee, M.Y Loh, Y.R Tan, Y.B Ng, E.Y Lescar, J Kang, C Luo, D
author_sort	Phoo, W.W
title	Structure of the NS2B-NS3 protease from Zika virus after self-cleavage
title_short	Structure of the NS2B-NS3 protease from Zika virus after self-cleavage
title_full	Structure of the NS2B-NS3 protease from Zika virus after self-cleavage
title_fullStr	Structure of the NS2B-NS3 protease from Zika virus after self-cleavage
title_full_unstemmed	Structure of the NS2B-NS3 protease from Zika virus after self-cleavage
title_sort	structure of the ns2b-ns3 protease from zika virus after self-cleavage
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/179788
_version_	1779152572047687680

Structure of the NS2B-NS3 protease from Zika virus after self-cleavage

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