Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS

Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS

10.1186/s40478-015-0212-4

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Bibliographic Details
Main Authors:	Mitchell, J.C, Constable, R, So, E, Vance, C, Scotter, E, Glover, L, Hortobagyi, T, Arnold, E.S, Ling, S.-C, McAlonis, M, Da Cruz, S, Polymenidou, M, Tessarolo, L, Cleveland, D.W, Shaw, C.E
Other Authors:	PHYSIOLOGY
Format:	Article
Published:	2020
Subjects:	DNA binding protein leukocyte antigen nerve protein TDP-43 protein, human age amyotrophic lateral sclerosis animal brain cortex C57BL mouse cytoplasm disease course disease model gene expression regulation genetics human metabolism mouse mutation nerve cell pathology pathophysiology spinal cord transgenic mouse Age Factors Amyotrophic Lateral Sclerosis Animals Antigens, CD Cerebral Cortex Cytoplasm Disease Models, Animal Disease Progression DNA-Binding Proteins Gene Expression Regulation Humans Mice Mice, Inbred C57BL Mice, Transgenic Mutation Nerve Tissue Proteins Neurons Spinal Cord
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/180330
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Institution:	National University of Singapore

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Summary:	10.1186/s40478-015-0212-4