Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS

• Main Authors: Mitchell, J.C, Constable, R, So, E, Vance, C, Scotter, E, Glover, L, Hortobagyi, T, Arnold, E.S, Ling, S.-C, McAlonis, M, Da Cruz, S, Polymenidou, M, Tessarolo, L, Cleveland, D.W, Shaw, C.E
• Other Authors: PHYSIOLOGY
• Format: Article
• Published: 2020
• Subjects: DNA binding protein; leukocyte antigen; nerve protein; TDP-43 protein, human; age; amyotrophic lateral sclerosis; animal; brain cortex; C57BL mouse; cytoplasm; disease course; disease model; gene expression regulation; genetics; human; metabolism; mouse; mutation; nerve cell; pathology; pathophysiology; spinal cord; transgenic mouse; Age Factors; Amyotrophic Lateral Sclerosis; Animals; Antigens, CD; Cerebral Cortex; Cytoplasm; Disease Models, Animal; Disease Progression; DNA-Binding Proteins; Gene Expression Regulation; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Neurons; Spinal Cord
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/180330
• Institution: National University of Singapore

10.1186/s40478-015-0212-4