Flcn-deficient renal cells are tumorigenic and sensitive to mTOR suppression

10.18632/oncotarget.5018

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Main Authors:	Wu, M, Si, S, Li, Y, Schoen, S, Xiao, G.-Q, Li, X, Teh, B.T, Wu, G, Chen, J
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	2020
Subjects:	estrone mammalian target of rapamycin rapamycin antineoplastic agent Bhd protein, mouse FLCN protein, human MTOR protein, human mTOR protein, mouse oncoprotein protein kinase inhibitor target of rapamycin kinase tumor suppressor protein animal cell animal experiment animal model animal tissue antineoplastic activity Article Birt Hogg Dube syndrome cancer inhibition carcinogenesis controlled study human human cell kidney carcinoma kidney tubule cell mouse nonhuman phenotype signal transduction tumor xenograft upregulation allograft animal antagonists and inhibitors Carcinoma, Renal Cell cell transformation deficiency drug effects drug screening enzymology gene expression regulation genetic predisposition genetics Kidney Neoplasms knockout mouse metabolism molecularly targeted therapy nude mouse pathology time factor tumor cell line tumor volume Allografts Animals Antineoplastic Agents Cell Line, Tumor Cell Transformation, Neoplastic Gene Expression Regulation, Neoplastic Genetic Predisposition to Disease Humans Mice, Knockout Mice, Nude Molecular Targeted Therapy Phenotype Protein Kinase Inhibitors Proto-Oncogene Proteins Signal Transduction Sirolimus Time Factors TOR Serine-Threonine Kinases Tumor Burden Tumor Suppressor Proteins Xenograft Model Antitumor Assays
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/180935
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1809352023-10-31T21:24:00Z Flcn-deficient renal cells are tumorigenic and sensitive to mTOR suppression Wu, M Si, S Li, Y Schoen, S Xiao, G.-Q Li, X Teh, B.T Wu, G Chen, J DUKE-NUS MEDICAL SCHOOL estrone mammalian target of rapamycin rapamycin antineoplastic agent Bhd protein, mouse FLCN protein, human MTOR protein, human mTOR protein, mouse oncoprotein protein kinase inhibitor rapamycin target of rapamycin kinase tumor suppressor protein animal cell animal experiment animal model animal tissue antineoplastic activity Article Birt Hogg Dube syndrome cancer inhibition carcinogenesis controlled study human human cell kidney carcinoma kidney tubule cell mouse nonhuman phenotype signal transduction tumor xenograft upregulation allograft animal antagonists and inhibitors Carcinoma, Renal Cell cell transformation deficiency drug effects drug screening enzymology gene expression regulation genetic predisposition genetics Kidney Neoplasms knockout mouse metabolism molecularly targeted therapy nude mouse pathology time factor tumor cell line tumor volume Allografts Animals Antineoplastic Agents Carcinoma, Renal Cell Cell Line, Tumor Cell Transformation, Neoplastic Gene Expression Regulation, Neoplastic Genetic Predisposition to Disease Humans Kidney Neoplasms Mice, Knockout Mice, Nude Molecular Targeted Therapy Phenotype Protein Kinase Inhibitors Proto-Oncogene Proteins Signal Transduction Sirolimus Time Factors TOR Serine-Threonine Kinases Tumor Burden Tumor Suppressor Proteins Xenograft Model Antitumor Assays 10.18632/oncotarget.5018 Oncotarget 6 32 32761-32773 2020-10-27T05:46:23Z 2020-10-27T05:46:23Z 2015 Article Wu, M, Si, S, Li, Y, Schoen, S, Xiao, G.-Q, Li, X, Teh, B.T, Wu, G, Chen, J (2015). Flcn-deficient renal cells are tumorigenic and sensitive to mTOR suppression. Oncotarget 6 (32) : 32761-32773. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.5018 19492553 https://scholarbank.nus.edu.sg/handle/10635/180935 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	estrone mammalian target of rapamycin rapamycin antineoplastic agent Bhd protein, mouse FLCN protein, human MTOR protein, human mTOR protein, mouse oncoprotein protein kinase inhibitor rapamycin target of rapamycin kinase tumor suppressor protein animal cell animal experiment animal model animal tissue antineoplastic activity Article Birt Hogg Dube syndrome cancer inhibition carcinogenesis controlled study human human cell kidney carcinoma kidney tubule cell mouse nonhuman phenotype signal transduction tumor xenograft upregulation allograft animal antagonists and inhibitors Carcinoma, Renal Cell cell transformation deficiency drug effects drug screening enzymology gene expression regulation genetic predisposition genetics Kidney Neoplasms knockout mouse metabolism molecularly targeted therapy nude mouse pathology time factor tumor cell line tumor volume Allografts Animals Antineoplastic Agents Carcinoma, Renal Cell Cell Line, Tumor Cell Transformation, Neoplastic Gene Expression Regulation, Neoplastic Genetic Predisposition to Disease Humans Kidney Neoplasms Mice, Knockout Mice, Nude Molecular Targeted Therapy Phenotype Protein Kinase Inhibitors Proto-Oncogene Proteins Signal Transduction Sirolimus Time Factors TOR Serine-Threonine Kinases Tumor Burden Tumor Suppressor Proteins Xenograft Model Antitumor Assays
spellingShingle	estrone mammalian target of rapamycin rapamycin antineoplastic agent Bhd protein, mouse FLCN protein, human MTOR protein, human mTOR protein, mouse oncoprotein protein kinase inhibitor rapamycin target of rapamycin kinase tumor suppressor protein animal cell animal experiment animal model animal tissue antineoplastic activity Article Birt Hogg Dube syndrome cancer inhibition carcinogenesis controlled study human human cell kidney carcinoma kidney tubule cell mouse nonhuman phenotype signal transduction tumor xenograft upregulation allograft animal antagonists and inhibitors Carcinoma, Renal Cell cell transformation deficiency drug effects drug screening enzymology gene expression regulation genetic predisposition genetics Kidney Neoplasms knockout mouse metabolism molecularly targeted therapy nude mouse pathology time factor tumor cell line tumor volume Allografts Animals Antineoplastic Agents Carcinoma, Renal Cell Cell Line, Tumor Cell Transformation, Neoplastic Gene Expression Regulation, Neoplastic Genetic Predisposition to Disease Humans Kidney Neoplasms Mice, Knockout Mice, Nude Molecular Targeted Therapy Phenotype Protein Kinase Inhibitors Proto-Oncogene Proteins Signal Transduction Sirolimus Time Factors TOR Serine-Threonine Kinases Tumor Burden Tumor Suppressor Proteins Xenograft Model Antitumor Assays Wu, M Si, S Li, Y Schoen, S Xiao, G.-Q Li, X Teh, B.T Wu, G Chen, J Flcn-deficient renal cells are tumorigenic and sensitive to mTOR suppression
description	10.18632/oncotarget.5018
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Wu, M Si, S Li, Y Schoen, S Xiao, G.-Q Li, X Teh, B.T Wu, G Chen, J
format	Article
author	Wu, M Si, S Li, Y Schoen, S Xiao, G.-Q Li, X Teh, B.T Wu, G Chen, J
author_sort	Wu, M
title	Flcn-deficient renal cells are tumorigenic and sensitive to mTOR suppression
title_short	Flcn-deficient renal cells are tumorigenic and sensitive to mTOR suppression
title_full	Flcn-deficient renal cells are tumorigenic and sensitive to mTOR suppression
title_fullStr	Flcn-deficient renal cells are tumorigenic and sensitive to mTOR suppression
title_full_unstemmed	Flcn-deficient renal cells are tumorigenic and sensitive to mTOR suppression
title_sort	flcn-deficient renal cells are tumorigenic and sensitive to mtor suppression
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/180935
_version_	1781792420844797952

Flcn-deficient renal cells are tumorigenic and sensitive to mTOR suppression

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