The IκB kinase inhibitor ACHP strongly attenuates TGFβ1-induced myofibroblast formation and collagen synthesis

• Main Authors: Mia, M.M, Bank, R.A
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2020
• Subjects: I kappa B kinase beta; transforming growth factor beta1; 2-amino-6-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-4-piperidin-4-yl nicotinonitrile; ACTA2 protein, human; actin; actin binding protein; collagen type 1; fibronectin; I kappa B kinase; muscle protein; nicotinic acid derivative; nitrile; procollagen lysine 2 oxoglutarate 5 dioxygenase; RELA protein, human; Smad protein; transcription factor RelA; transgelin; Article; collagen synthesis; confocal laser microscopy; controlled study; extracellular matrix; human; human cell; immunofluorescence; myofibroblast; priority journal; real time polymerase chain reaction; RNA isolation; signal transduction; adult; antagonists and inhibitors; biosynthesis; cell culture; cell differentiation; confocal microscopy; cytology; drug effects; fibroblast; gene expression; genetics; lung; metabolism; reverse transcription polymerase chain reaction; skin; Actins; Adult; Cell Differentiation; Cells, Cultured; Collagen Type I; Fibroblasts; Fibronectins; Gene Expression; Humans; I-kappa B Kinase; Lung; Microfilament Proteins; Microscopy, Confocal; Muscle Proteins; Myofibroblasts; Nicotinic Acids; Nitriles; Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase; Reverse Transcriptase Polymerase Chain Reaction; Skin; Smad Proteins; Transcription Factor RelA; Transforming Growth Factor beta1
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/181417
• Institution: National University of Singapore

10.1111/jcmm.12661