The IκB kinase inhibitor ACHP strongly attenuates TGFβ1-induced myofibroblast formation and collagen synthesis

10.1111/jcmm.12661

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Main Authors:	Mia, M.M, Bank, R.A
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	2020
Subjects:	I kappa B kinase beta transforming growth factor beta1 2-amino-6-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-4-piperidin-4-yl nicotinonitrile ACTA2 protein, human actin actin binding protein collagen type 1 fibronectin I kappa B kinase muscle protein nicotinic acid derivative nitrile procollagen lysine 2 oxoglutarate 5 dioxygenase RELA protein, human Smad protein transcription factor RelA transgelin Article collagen synthesis confocal laser microscopy controlled study extracellular matrix human human cell immunofluorescence myofibroblast priority journal real time polymerase chain reaction RNA isolation signal transduction adult antagonists and inhibitors biosynthesis cell culture cell differentiation confocal microscopy cytology drug effects fibroblast gene expression genetics lung metabolism reverse transcription polymerase chain reaction skin Actins Adult Cell Differentiation Cells, Cultured Collagen Type I Fibroblasts Fibronectins Gene Expression Humans I-kappa B Kinase Lung Microfilament Proteins Microscopy, Confocal Muscle Proteins Myofibroblasts Nicotinic Acids Nitriles Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase Reverse Transcriptase Polymerase Chain Reaction Skin Smad Proteins Transcription Factor RelA Transforming Growth Factor beta1
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/181417
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1814172023-10-31T21:12:59Z The IκB kinase inhibitor ACHP strongly attenuates TGFβ1-induced myofibroblast formation and collagen synthesis Mia, M.M Bank, R.A DUKE-NUS MEDICAL SCHOOL I kappa B kinase beta transforming growth factor beta1 2-amino-6-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-4-piperidin-4-yl nicotinonitrile ACTA2 protein, human actin actin binding protein collagen type 1 fibronectin I kappa B kinase muscle protein nicotinic acid derivative nitrile procollagen lysine 2 oxoglutarate 5 dioxygenase RELA protein, human Smad protein transcription factor RelA transforming growth factor beta1 transgelin Article collagen synthesis confocal laser microscopy controlled study extracellular matrix human human cell immunofluorescence myofibroblast priority journal real time polymerase chain reaction RNA isolation signal transduction adult antagonists and inhibitors biosynthesis cell culture cell differentiation confocal microscopy cytology drug effects fibroblast gene expression genetics lung metabolism myofibroblast reverse transcription polymerase chain reaction skin Actins Adult Cell Differentiation Cells, Cultured Collagen Type I Fibroblasts Fibronectins Gene Expression Humans I-kappa B Kinase Lung Microfilament Proteins Microscopy, Confocal Muscle Proteins Myofibroblasts Nicotinic Acids Nitriles Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase Reverse Transcriptase Polymerase Chain Reaction Skin Smad Proteins Transcription Factor RelA Transforming Growth Factor beta1 10.1111/jcmm.12661 Journal of Cellular and Molecular Medicine 19 12 2780-2792 2020-10-27T10:51:34Z 2020-10-27T10:51:34Z 2015 Article Mia, M.M, Bank, R.A (2015). The IκB kinase inhibitor ACHP strongly attenuates TGFβ1-induced myofibroblast formation and collagen synthesis. Journal of Cellular and Molecular Medicine 19 (12) : 2780-2792. ScholarBank@NUS Repository. https://doi.org/10.1111/jcmm.12661 15821838 https://scholarbank.nus.edu.sg/handle/10635/181417 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	I kappa B kinase beta transforming growth factor beta1 2-amino-6-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-4-piperidin-4-yl nicotinonitrile ACTA2 protein, human actin actin binding protein collagen type 1 fibronectin I kappa B kinase muscle protein nicotinic acid derivative nitrile procollagen lysine 2 oxoglutarate 5 dioxygenase RELA protein, human Smad protein transcription factor RelA transforming growth factor beta1 transgelin Article collagen synthesis confocal laser microscopy controlled study extracellular matrix human human cell immunofluorescence myofibroblast priority journal real time polymerase chain reaction RNA isolation signal transduction adult antagonists and inhibitors biosynthesis cell culture cell differentiation confocal microscopy cytology drug effects fibroblast gene expression genetics lung metabolism myofibroblast reverse transcription polymerase chain reaction skin Actins Adult Cell Differentiation Cells, Cultured Collagen Type I Fibroblasts Fibronectins Gene Expression Humans I-kappa B Kinase Lung Microfilament Proteins Microscopy, Confocal Muscle Proteins Myofibroblasts Nicotinic Acids Nitriles Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase Reverse Transcriptase Polymerase Chain Reaction Skin Smad Proteins Transcription Factor RelA Transforming Growth Factor beta1
spellingShingle	I kappa B kinase beta transforming growth factor beta1 2-amino-6-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-4-piperidin-4-yl nicotinonitrile ACTA2 protein, human actin actin binding protein collagen type 1 fibronectin I kappa B kinase muscle protein nicotinic acid derivative nitrile procollagen lysine 2 oxoglutarate 5 dioxygenase RELA protein, human Smad protein transcription factor RelA transforming growth factor beta1 transgelin Article collagen synthesis confocal laser microscopy controlled study extracellular matrix human human cell immunofluorescence myofibroblast priority journal real time polymerase chain reaction RNA isolation signal transduction adult antagonists and inhibitors biosynthesis cell culture cell differentiation confocal microscopy cytology drug effects fibroblast gene expression genetics lung metabolism myofibroblast reverse transcription polymerase chain reaction skin Actins Adult Cell Differentiation Cells, Cultured Collagen Type I Fibroblasts Fibronectins Gene Expression Humans I-kappa B Kinase Lung Microfilament Proteins Microscopy, Confocal Muscle Proteins Myofibroblasts Nicotinic Acids Nitriles Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase Reverse Transcriptase Polymerase Chain Reaction Skin Smad Proteins Transcription Factor RelA Transforming Growth Factor beta1 Mia, M.M Bank, R.A The IκB kinase inhibitor ACHP strongly attenuates TGFβ1-induced myofibroblast formation and collagen synthesis
description	10.1111/jcmm.12661
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Mia, M.M Bank, R.A
format	Article
author	Mia, M.M Bank, R.A
author_sort	Mia, M.M
title	The IκB kinase inhibitor ACHP strongly attenuates TGFβ1-induced myofibroblast formation and collagen synthesis
title_short	The IκB kinase inhibitor ACHP strongly attenuates TGFβ1-induced myofibroblast formation and collagen synthesis
title_full	The IκB kinase inhibitor ACHP strongly attenuates TGFβ1-induced myofibroblast formation and collagen synthesis
title_fullStr	The IκB kinase inhibitor ACHP strongly attenuates TGFβ1-induced myofibroblast formation and collagen synthesis
title_full_unstemmed	The IκB kinase inhibitor ACHP strongly attenuates TGFβ1-induced myofibroblast formation and collagen synthesis
title_sort	iκb kinase inhibitor achp strongly attenuates tgfβ1-induced myofibroblast formation and collagen synthesis
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/181417
_version_	1781792506154844160

The IκB kinase inhibitor ACHP strongly attenuates TGFβ1-induced myofibroblast formation and collagen synthesis

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