PH Induced Conformational Transitions in the Transforming Growth Factor ?-Induced Protein (TGF?IP) Associated Corneal Dystrophy Mutants

• Main Authors: Murugan, E, Venkatraman, A, Lei, Z, Mouvet, V, Rui Yi Lim, R, Muruganantham, N, Goh, E, Swee Lim Peh, G, Beuerman, R.W, Chaurasia, S.S, Rajamani, L, Mehta, J.S
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: amyloid protein; betaIG-H3 protein; recombinant protein; scleroprotein; transforming growth factor beta; amino acid sequence; cell survival; chemistry; congenital cornea dystrophy; cornea stroma; cytology; drug effects; Escherichia coli; fibroblast; gene expression; genetics; human; metabolism; molecular cloning; mutation; pathology; pH; primary cell culture; protein denaturation; protein domain; protein secondary structure; protein stability; Amino Acid Sequence; Amyloidogenic Proteins; Cell Survival; Cloning, Molecular; Corneal Dystrophies, Hereditary; Corneal Stroma; Extracellular Matrix Proteins; Fibroblasts; Gene Expression; Humans; Hydrogen-Ion Concentration; Mutation; Primary Cell Culture; Protein Denaturation; Protein Domains; Protein Stability; Protein Structure, Secondary; Recombinant Proteins; Transforming Growth Factor beta
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/182487
• Institution: National University of Singapore

10.1038/srep23836