Hypaphorine attenuates lipopolysaccharide-induced endothelial inflammation via regulation of TLR4 and PPAR-γ dependent on PI3K/Akt/mTOR signal pathway

• Main Authors: Sun, H, Zhu, X, Cai, W, Qiu, L
• Other Authors: DEPT OF PHARMACOLOGY
• Format: Article
• Published: MDPI 2020
• Subjects: hypaphorine; indole alkaloid; interleukin 1beta; lipopolysaccharide; monocyte chemotactic protein 1; peroxisome proliferator activated receptor gamma; phosphatidylinositol 3 kinase; protein kinase B; rapamycin; toll like receptor 4; tumor necrosis factor; unclassified drug; vascular cell adhesion molecule 1; autacoid; biological marker; cytokine; indole derivative; lenticin; protein binding; target of rapamycin kinase; Article; cell culture; controlled study; densitometry; enzyme linked immunosorbent assay; human; human cell; immunofluorescence microscopy; inflammation; real time polymerase chain reaction; signal transduction; stimulation; Western blotting; drug effects; enzyme activation; genetics; metabolism; pathology; vascular endothelium; Biomarkers; Cytokines; Endothelium, Vascular; Enzyme Activation; Humans; Indoles; Inflammation; Inflammation Mediators; Lipopolysaccharides; Phosphatidylinositol 3-Kinases; PPAR gamma; Protein Binding; Proto-Oncogene Proteins c-akt; Signal Transduction; Toll-Like Receptor 4; TOR Serine-Threonine Kinases
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/183535
• Institution: National University of Singapore

10.3390/ijms18040844