Hypaphorine attenuates lipopolysaccharide-induced endothelial inflammation via regulation of TLR4 and PPAR-γ dependent on PI3K/Akt/mTOR signal pathway

10.3390/ijms18040844

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Main Authors:	Sun, H, Zhu, X, Cai, W, Qiu, L
Other Authors:	DEPT OF PHARMACOLOGY
Format:	Article
Published:	MDPI 2020
Subjects:	hypaphorine indole alkaloid interleukin 1beta lipopolysaccharide monocyte chemotactic protein 1 peroxisome proliferator activated receptor gamma phosphatidylinositol 3 kinase protein kinase B rapamycin toll like receptor 4 tumor necrosis factor unclassified drug vascular cell adhesion molecule 1 autacoid biological marker cytokine indole derivative lenticin protein binding target of rapamycin kinase Article cell culture controlled study densitometry enzyme linked immunosorbent assay human human cell immunofluorescence microscopy inflammation real time polymerase chain reaction signal transduction stimulation Western blotting drug effects enzyme activation genetics metabolism pathology vascular endothelium Biomarkers Cytokines Endothelium, Vascular Enzyme Activation Humans Indoles Inflammation Inflammation Mediators Lipopolysaccharides Phosphatidylinositol 3-Kinases PPAR gamma Protein Binding Proto-Oncogene Proteins c-akt Signal Transduction Toll-Like Receptor 4 TOR Serine-Threonine Kinases
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/183535
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1835352023-11-01T07:49:59Z Hypaphorine attenuates lipopolysaccharide-induced endothelial inflammation via regulation of TLR4 and PPAR-γ dependent on PI3K/Akt/mTOR signal pathway Sun, H Zhu, X Cai, W Qiu, L DEPT OF PHARMACOLOGY hypaphorine indole alkaloid interleukin 1beta lipopolysaccharide monocyte chemotactic protein 1 peroxisome proliferator activated receptor gamma phosphatidylinositol 3 kinase protein kinase B rapamycin toll like receptor 4 tumor necrosis factor unclassified drug vascular cell adhesion molecule 1 autacoid biological marker cytokine indole derivative lenticin lipopolysaccharide peroxisome proliferator activated receptor gamma phosphatidylinositol 3 kinase protein binding protein kinase B target of rapamycin kinase toll like receptor 4 Article cell culture controlled study densitometry enzyme linked immunosorbent assay human human cell immunofluorescence microscopy inflammation real time polymerase chain reaction signal transduction stimulation Western blotting drug effects enzyme activation genetics inflammation metabolism pathology signal transduction vascular endothelium Biomarkers Cytokines Endothelium, Vascular Enzyme Activation Humans Indoles Inflammation Inflammation Mediators Lipopolysaccharides Phosphatidylinositol 3-Kinases PPAR gamma Protein Binding Proto-Oncogene Proteins c-akt Signal Transduction Toll-Like Receptor 4 TOR Serine-Threonine Kinases 10.3390/ijms18040844 International Journal of Molecular Sciences 18 4 844 2020-11-17T06:33:38Z 2020-11-17T06:33:38Z 2017 Article Sun, H, Zhu, X, Cai, W, Qiu, L (2017). Hypaphorine attenuates lipopolysaccharide-induced endothelial inflammation via regulation of TLR4 and PPAR-γ dependent on PI3K/Akt/mTOR signal pathway. International Journal of Molecular Sciences 18 (4) : 844. ScholarBank@NUS Repository. https://doi.org/10.3390/ijms18040844 1661-6596 https://scholarbank.nus.edu.sg/handle/10635/183535 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ MDPI Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	hypaphorine indole alkaloid interleukin 1beta lipopolysaccharide monocyte chemotactic protein 1 peroxisome proliferator activated receptor gamma phosphatidylinositol 3 kinase protein kinase B rapamycin toll like receptor 4 tumor necrosis factor unclassified drug vascular cell adhesion molecule 1 autacoid biological marker cytokine indole derivative lenticin lipopolysaccharide peroxisome proliferator activated receptor gamma phosphatidylinositol 3 kinase protein binding protein kinase B target of rapamycin kinase toll like receptor 4 Article cell culture controlled study densitometry enzyme linked immunosorbent assay human human cell immunofluorescence microscopy inflammation real time polymerase chain reaction signal transduction stimulation Western blotting drug effects enzyme activation genetics inflammation metabolism pathology signal transduction vascular endothelium Biomarkers Cytokines Endothelium, Vascular Enzyme Activation Humans Indoles Inflammation Inflammation Mediators Lipopolysaccharides Phosphatidylinositol 3-Kinases PPAR gamma Protein Binding Proto-Oncogene Proteins c-akt Signal Transduction Toll-Like Receptor 4 TOR Serine-Threonine Kinases
spellingShingle	hypaphorine indole alkaloid interleukin 1beta lipopolysaccharide monocyte chemotactic protein 1 peroxisome proliferator activated receptor gamma phosphatidylinositol 3 kinase protein kinase B rapamycin toll like receptor 4 tumor necrosis factor unclassified drug vascular cell adhesion molecule 1 autacoid biological marker cytokine indole derivative lenticin lipopolysaccharide peroxisome proliferator activated receptor gamma phosphatidylinositol 3 kinase protein binding protein kinase B target of rapamycin kinase toll like receptor 4 Article cell culture controlled study densitometry enzyme linked immunosorbent assay human human cell immunofluorescence microscopy inflammation real time polymerase chain reaction signal transduction stimulation Western blotting drug effects enzyme activation genetics inflammation metabolism pathology signal transduction vascular endothelium Biomarkers Cytokines Endothelium, Vascular Enzyme Activation Humans Indoles Inflammation Inflammation Mediators Lipopolysaccharides Phosphatidylinositol 3-Kinases PPAR gamma Protein Binding Proto-Oncogene Proteins c-akt Signal Transduction Toll-Like Receptor 4 TOR Serine-Threonine Kinases Sun, H Zhu, X Cai, W Qiu, L Hypaphorine attenuates lipopolysaccharide-induced endothelial inflammation via regulation of TLR4 and PPAR-γ dependent on PI3K/Akt/mTOR signal pathway
description	10.3390/ijms18040844
author2	DEPT OF PHARMACOLOGY
author_facet	DEPT OF PHARMACOLOGY Sun, H Zhu, X Cai, W Qiu, L
format	Article
author	Sun, H Zhu, X Cai, W Qiu, L
author_sort	Sun, H
title	Hypaphorine attenuates lipopolysaccharide-induced endothelial inflammation via regulation of TLR4 and PPAR-γ dependent on PI3K/Akt/mTOR signal pathway
title_short	Hypaphorine attenuates lipopolysaccharide-induced endothelial inflammation via regulation of TLR4 and PPAR-γ dependent on PI3K/Akt/mTOR signal pathway
title_full	Hypaphorine attenuates lipopolysaccharide-induced endothelial inflammation via regulation of TLR4 and PPAR-γ dependent on PI3K/Akt/mTOR signal pathway
title_fullStr	Hypaphorine attenuates lipopolysaccharide-induced endothelial inflammation via regulation of TLR4 and PPAR-γ dependent on PI3K/Akt/mTOR signal pathway
title_full_unstemmed	Hypaphorine attenuates lipopolysaccharide-induced endothelial inflammation via regulation of TLR4 and PPAR-γ dependent on PI3K/Akt/mTOR signal pathway
title_sort	hypaphorine attenuates lipopolysaccharide-induced endothelial inflammation via regulation of tlr4 and ppar-γ dependent on pi3k/akt/mtor signal pathway
publisher	MDPI
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/183535
_version_	1781792633973112832

Hypaphorine attenuates lipopolysaccharide-induced endothelial inflammation via regulation of TLR4 and PPAR-γ dependent on PI3K/Akt/mTOR signal pathway

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