Immunosuppression overcomes insulin- and vector-specific immune responses that limit efficacy of AAV2/8-mediated insulin gene therapy in NOD mice

10.1038/s41434-018-0052-5

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Main Authors:	Recino, Asha, Gan, Shu Uin, Sia, Kian Chuan, Sawyer, Yvonne, Trendell, Jenny, Kay, Richard, Gribble, Fiona M, Reimann, Frank, Foale, Rob, Notaridou, Maria, Holmes, Nick, Lever, Andrew, Lee, Kok Onn, Nathwani, Amit, Cooke, Anne, Calne, Roy, Wallberg, Maja
Other Authors:	MEDICINE
Format:	Article
Language:	English
Published:	NATURE PUBLISHING GROUP 2021
Subjects:	Science & Technology Life Sciences & Biomedicine Biochemistry & Molecular Biology Biotechnology & Applied Microbiology Genetics & Heredity Medicine, Research & Experimental Research & Experimental Medicine ISLET GRAFTS MURINE LIVER CELLS EXPRESSION TOLERANCE IDENTIFICATION ACTIVATION ANTI-CD4 REVERSAL DELIVERY
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/205977
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Institution:	National University of Singapore
Language:	English

id	sg-nus-scholar.10635-205977
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spelling	sg-nus-scholar.10635-2059772024-04-25T01:21:54Z Immunosuppression overcomes insulin- and vector-specific immune responses that limit efficacy of AAV2/8-mediated insulin gene therapy in NOD mice Recino, Asha Gan, Shu Uin Sia, Kian Chuan Sawyer, Yvonne Trendell, Jenny Kay, Richard Gribble, Fiona M Reimann, Frank Foale, Rob Notaridou, Maria Holmes, Nick Lever, Andrew Lee, Kok Onn Nathwani, Amit Cooke, Anne Calne, Roy Wallberg, Maja MEDICINE SURGERY Science & Technology Life Sciences & Biomedicine Biochemistry & Molecular Biology Biotechnology & Applied Microbiology Genetics & Heredity Medicine, Research & Experimental Research & Experimental Medicine ISLET GRAFTS MURINE LIVER CELLS EXPRESSION TOLERANCE IDENTIFICATION ACTIVATION ANTI-CD4 REVERSAL DELIVERY 10.1038/s41434-018-0052-5 GENE THERAPY 26 1-Feb 40-56 completed 2021-11-11T10:15:54Z 2021-11-11T10:15:54Z 2019-02-01 2021-11-10T02:04:21Z Article Recino, Asha, Gan, Shu Uin, Sia, Kian Chuan, Sawyer, Yvonne, Trendell, Jenny, Kay, Richard, Gribble, Fiona M, Reimann, Frank, Foale, Rob, Notaridou, Maria, Holmes, Nick, Lever, Andrew, Lee, Kok Onn, Nathwani, Amit, Cooke, Anne, Calne, Roy, Wallberg, Maja (2019-02-01). Immunosuppression overcomes insulin- and vector-specific immune responses that limit efficacy of AAV2/8-mediated insulin gene therapy in NOD mice. GENE THERAPY 26 (1-Feb) : 40-56. ScholarBank@NUS Repository. https://doi.org/10.1038/s41434-018-0052-5 09697128 14765462 https://scholarbank.nus.edu.sg/handle/10635/205977 en NATURE PUBLISHING GROUP Elements
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
language	English
topic	Science & Technology Life Sciences & Biomedicine Biochemistry & Molecular Biology Biotechnology & Applied Microbiology Genetics & Heredity Medicine, Research & Experimental Research & Experimental Medicine ISLET GRAFTS MURINE LIVER CELLS EXPRESSION TOLERANCE IDENTIFICATION ACTIVATION ANTI-CD4 REVERSAL DELIVERY
spellingShingle	Science & Technology Life Sciences & Biomedicine Biochemistry & Molecular Biology Biotechnology & Applied Microbiology Genetics & Heredity Medicine, Research & Experimental Research & Experimental Medicine ISLET GRAFTS MURINE LIVER CELLS EXPRESSION TOLERANCE IDENTIFICATION ACTIVATION ANTI-CD4 REVERSAL DELIVERY Recino, Asha Gan, Shu Uin Sia, Kian Chuan Sawyer, Yvonne Trendell, Jenny Kay, Richard Gribble, Fiona M Reimann, Frank Foale, Rob Notaridou, Maria Holmes, Nick Lever, Andrew Lee, Kok Onn Nathwani, Amit Cooke, Anne Calne, Roy Wallberg, Maja Immunosuppression overcomes insulin- and vector-specific immune responses that limit efficacy of AAV2/8-mediated insulin gene therapy in NOD mice
description	10.1038/s41434-018-0052-5
author2	MEDICINE
author_facet	MEDICINE Recino, Asha Gan, Shu Uin Sia, Kian Chuan Sawyer, Yvonne Trendell, Jenny Kay, Richard Gribble, Fiona M Reimann, Frank Foale, Rob Notaridou, Maria Holmes, Nick Lever, Andrew Lee, Kok Onn Nathwani, Amit Cooke, Anne Calne, Roy Wallberg, Maja
format	Article
author	Recino, Asha Gan, Shu Uin Sia, Kian Chuan Sawyer, Yvonne Trendell, Jenny Kay, Richard Gribble, Fiona M Reimann, Frank Foale, Rob Notaridou, Maria Holmes, Nick Lever, Andrew Lee, Kok Onn Nathwani, Amit Cooke, Anne Calne, Roy Wallberg, Maja
author_sort	Recino, Asha
title	Immunosuppression overcomes insulin- and vector-specific immune responses that limit efficacy of AAV2/8-mediated insulin gene therapy in NOD mice
title_short	Immunosuppression overcomes insulin- and vector-specific immune responses that limit efficacy of AAV2/8-mediated insulin gene therapy in NOD mice
title_full	Immunosuppression overcomes insulin- and vector-specific immune responses that limit efficacy of AAV2/8-mediated insulin gene therapy in NOD mice
title_fullStr	Immunosuppression overcomes insulin- and vector-specific immune responses that limit efficacy of AAV2/8-mediated insulin gene therapy in NOD mice
title_full_unstemmed	Immunosuppression overcomes insulin- and vector-specific immune responses that limit efficacy of AAV2/8-mediated insulin gene therapy in NOD mice
title_sort	immunosuppression overcomes insulin- and vector-specific immune responses that limit efficacy of aav2/8-mediated insulin gene therapy in nod mice
publisher	NATURE PUBLISHING GROUP
publishDate	2021
url	https://scholarbank.nus.edu.sg/handle/10635/205977
_version_	1800915063561781248

Immunosuppression overcomes insulin- and vector-specific immune responses that limit efficacy of AAV2/8-mediated insulin gene therapy in NOD mice

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