Immunosuppression overcomes insulin- and vector-specific immune responses that limit efficacy of AAV2/8-mediated insulin gene therapy in NOD mice

• Main Authors: Recino, Asha, Gan, Shu Uin, Sia, Kian Chuan, Sawyer, Yvonne, Trendell, Jenny, Kay, Richard, Gribble, Fiona M, Reimann, Frank, Foale, Rob, Notaridou, Maria, Holmes, Nick, Lever, Andrew, Lee, Kok Onn, Nathwani, Amit, Cooke, Anne, Calne, Roy, Wallberg, Maja
• Other Authors: MEDICINE
• Format: Article
• Language: English
• Published: NATURE PUBLISHING GROUP 2021
• Subjects: Science & Technology; Life Sciences & Biomedicine; Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine, Research & Experimental; Research & Experimental Medicine; ISLET GRAFTS; MURINE LIVER; CELLS; EXPRESSION; TOLERANCE; IDENTIFICATION; ACTIVATION; ANTI-CD4; REVERSAL; DELIVERY
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/205977
• Institution: National University of Singapore

10.1038/s41434-018-0052-5