Integrated Genomic Profiling and Drug Screening of Patient-Derived Cultures Identifies Individualized Copy Number-Dependent Susceptibilities Involving PI3K Pathway and 17q Genes in Neuroblastoma

Integrated Genomic Profiling and Drug Screening of Patient-Derived Cultures Identifies Individualized Copy Number-Dependent Susceptibilities Involving PI3K Pathway and 17q Genes in Neuroblastoma

10.3389/fonc.2021.709525

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Bibliographic Details
Main Authors: Wong, Rachel LY, Wong, Megan RE, Kuick, Chik Hong, Saffari, Seyed Ehsan, Wong, Meng Kang, Tan, Sheng Hui, Merchant, Khurshid, Chang, Kenneth TE, Thangavelu, Matan, Periyasamy, Giridharan, Chen, Zhi Xiong, Iyer, Prasad, Tan, Enrica EK, Soh, Shui Yen, Iyer, N Gopalakrishna, Fan, Qiao, Loh, Amos HP
Other Authors: DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
Format: Article
Language:English
Published: FRONTIERS MEDIA SA 2022
Subjects:
Science & Technology
Life Sciences & Biomedicine
Oncology
neuroblastoma
patient-derived culture
copy number variations (CNV)
Comprehensive genomic profiling (CGP)
PI3K
AKT pathway
CDK (cyclin-dependent kinase)
JAK-STAT cascade
SEGMENTAL CHROMOSOMAL ALTERATIONS
HUMAN TUMOR XENOGRAFTS
IN-VITRO
KINASE INHIBITOR
MYCN PROTEIN
CELL-LINE
CANCER
TARGET
MODELS
GROWTH
Online Access:https://scholarbank.nus.edu.sg/handle/10635/218658
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Institution: National University of Singapore
Language: English

Internet

https://scholarbank.nus.edu.sg/handle/10635/218658

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