Integrated Genomic Profiling and Drug Screening of Patient-Derived Cultures Identifies Individualized Copy Number-Dependent Susceptibilities Involving PI3K Pathway and 17q Genes in Neuroblastoma

• Main Authors: Wong, Rachel LY, Wong, Megan RE, Kuick, Chik Hong, Saffari, Seyed Ehsan, Wong, Meng Kang, Tan, Sheng Hui, Merchant, Khurshid, Chang, Kenneth TE, Thangavelu, Matan, Periyasamy, Giridharan, Chen, Zhi Xiong, Iyer, Prasad, Tan, Enrica EK, Soh, Shui Yen, Iyer, N Gopalakrishna, Fan, Qiao, Loh, Amos HP
• Other Authors: DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
• Format: Article
• Language: English
• Published: FRONTIERS MEDIA SA 2022
• Subjects: Science & Technology; Life Sciences & Biomedicine; Oncology; neuroblastoma; patient-derived culture; copy number variations (CNV); Comprehensive genomic profiling (CGP); PI3K; AKT pathway; CDK (cyclin-dependent kinase); JAK-STAT cascade; SEGMENTAL CHROMOSOMAL ALTERATIONS; HUMAN TUMOR XENOGRAFTS; IN-VITRO; KINASE INHIBITOR; MYCN PROTEIN; CELL-LINE; CANCER; TARGET; MODELS; GROWTH
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/218658
• Institution: National University of Singapore

10.3389/fonc.2021.709525