Integrated Genomic Profiling and Drug Screening of Patient-Derived Cultures Identifies Individualized Copy Number-Dependent Susceptibilities Involving PI3K Pathway and 17q Genes in Neuroblastoma

Integrated Genomic Profiling and Drug Screening of Patient-Derived Cultures Identifies Individualized Copy Number-Dependent Susceptibilities Involving PI3K Pathway and 17q Genes in Neuroblastoma

10.3389/fonc.2021.709525

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Bibliographic Details
Main Authors:	Wong, Rachel LY, Wong, Megan RE, Kuick, Chik Hong, Saffari, Seyed Ehsan, Wong, Meng Kang, Tan, Sheng Hui, Merchant, Khurshid, Chang, Kenneth TE, Thangavelu, Matan, Periyasamy, Giridharan, Chen, Zhi Xiong, Iyer, Prasad, Tan, Enrica EK, Soh, Shui Yen, Iyer, N Gopalakrishna, Fan, Qiao, Loh, Amos HP
Other Authors:	DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
Format:	Article
Language:	English
Published:	FRONTIERS MEDIA SA 2022
Subjects:	Science & Technology Life Sciences & Biomedicine Oncology neuroblastoma patient-derived culture copy number variations (CNV) Comprehensive genomic profiling (CGP) PI3K AKT pathway CDK (cyclin-dependent kinase) JAK-STAT cascade SEGMENTAL CHROMOSOMAL ALTERATIONS HUMAN TUMOR XENOGRAFTS IN-VITRO KINASE INHIBITOR MYCN PROTEIN CELL-LINE CANCER TARGET MODELS GROWTH
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/218658
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Institution:	National University of Singapore
Language:	English

Description
Summary:	10.3389/fonc.2021.709525