The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody

10.1371/journal.pone.0253487

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Main Authors:	Chan, Conrad E. Z., Seah, Shirley G. K., Chye, De Hoe, Massey, Shane, Torres, Maricela, Lim, Angeline P. C., Wong, Steven K. K., Neo, Jacklyn J. Y., Wong, Pui San, Lim, Jie Hui, Loh, Gary S. L., Wang, Dongling, Boyd-Kirkup, Jerome D., Guan, Siyu, Thakkar, Dipti, Teo, Guo Hui, Purushotorman, Kiren, Hutchinson, Paul E., Young, Barnaby E., Low, Jenny G., MacAry, Paul A., Hentze, Hannes, Prativadibhayankara, Venkateshan S., Ethirajulu, Kantharaj, Comer, Jason E., Tseng, Chien-Te K., Barrett, Alan D. T., Ingram, Piers J., Brasel, Trevor, Hanson, Brendon John
Other Authors:	LIFE SCIENCES INSTITUTE
Format:	Article
Published:	Public Library of Science 2022
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/232071
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-2320712023-10-31T08:42:31Z The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody Chan, Conrad E. Z. Seah, Shirley G. K. Chye, De Hoe Massey, Shane Torres, Maricela Lim, Angeline P. C. Wong, Steven K. K. Neo, Jacklyn J. Y. Wong, Pui San Lim, Jie Hui Loh, Gary S. L. Wang, Dongling Boyd-Kirkup, Jerome D. Guan, Siyu Thakkar, Dipti Teo, Guo Hui Purushotorman, Kiren Hutchinson, Paul E. Young, Barnaby E. Low, Jenny G. MacAry, Paul A. Hentze, Hannes Prativadibhayankara, Venkateshan S. Ethirajulu, Kantharaj Comer, Jason E. Tseng, Chien-Te K. Barrett, Alan D. T. Ingram, Piers J. Brasel, Trevor Hanson, Brendon John LIFE SCIENCES INSTITUTE MICROBIOLOGY AND IMMUNOLOGY DUKE-NUS MEDICAL SCHOOL 10.1371/journal.pone.0253487 PLoS ONE 16 6-Jun e0253487 2022-10-11T07:57:39Z 2022-10-11T07:57:39Z 2021-06-23 Article Chan, Conrad E. Z., Seah, Shirley G. K., Chye, De Hoe, Massey, Shane, Torres, Maricela, Lim, Angeline P. C., Wong, Steven K. K., Neo, Jacklyn J. Y., Wong, Pui San, Lim, Jie Hui, Loh, Gary S. L., Wang, Dongling, Boyd-Kirkup, Jerome D., Guan, Siyu, Thakkar, Dipti, Teo, Guo Hui, Purushotorman, Kiren, Hutchinson, Paul E., Young, Barnaby E., Low, Jenny G., MacAry, Paul A., Hentze, Hannes, Prativadibhayankara, Venkateshan S., Ethirajulu, Kantharaj, Comer, Jason E., Tseng, Chien-Te K., Barrett, Alan D. T., Ingram, Piers J., Brasel, Trevor, Hanson, Brendon John (2021-06-23). The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody. PLoS ONE 16 (6-Jun) : e0253487. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0253487 1932-6203 https://scholarbank.nus.edu.sg/handle/10635/232071 Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/ Public Library of Science Scopus OA2021
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
description	10.1371/journal.pone.0253487
author2	LIFE SCIENCES INSTITUTE
author_facet	LIFE SCIENCES INSTITUTE Chan, Conrad E. Z. Seah, Shirley G. K. Chye, De Hoe Massey, Shane Torres, Maricela Lim, Angeline P. C. Wong, Steven K. K. Neo, Jacklyn J. Y. Wong, Pui San Lim, Jie Hui Loh, Gary S. L. Wang, Dongling Boyd-Kirkup, Jerome D. Guan, Siyu Thakkar, Dipti Teo, Guo Hui Purushotorman, Kiren Hutchinson, Paul E. Young, Barnaby E. Low, Jenny G. MacAry, Paul A. Hentze, Hannes Prativadibhayankara, Venkateshan S. Ethirajulu, Kantharaj Comer, Jason E. Tseng, Chien-Te K. Barrett, Alan D. T. Ingram, Piers J. Brasel, Trevor Hanson, Brendon John
format	Article
author	Chan, Conrad E. Z. Seah, Shirley G. K. Chye, De Hoe Massey, Shane Torres, Maricela Lim, Angeline P. C. Wong, Steven K. K. Neo, Jacklyn J. Y. Wong, Pui San Lim, Jie Hui Loh, Gary S. L. Wang, Dongling Boyd-Kirkup, Jerome D. Guan, Siyu Thakkar, Dipti Teo, Guo Hui Purushotorman, Kiren Hutchinson, Paul E. Young, Barnaby E. Low, Jenny G. MacAry, Paul A. Hentze, Hannes Prativadibhayankara, Venkateshan S. Ethirajulu, Kantharaj Comer, Jason E. Tseng, Chien-Te K. Barrett, Alan D. T. Ingram, Piers J. Brasel, Trevor Hanson, Brendon John
spellingShingle	Chan, Conrad E. Z. Seah, Shirley G. K. Chye, De Hoe Massey, Shane Torres, Maricela Lim, Angeline P. C. Wong, Steven K. K. Neo, Jacklyn J. Y. Wong, Pui San Lim, Jie Hui Loh, Gary S. L. Wang, Dongling Boyd-Kirkup, Jerome D. Guan, Siyu Thakkar, Dipti Teo, Guo Hui Purushotorman, Kiren Hutchinson, Paul E. Young, Barnaby E. Low, Jenny G. MacAry, Paul A. Hentze, Hannes Prativadibhayankara, Venkateshan S. Ethirajulu, Kantharaj Comer, Jason E. Tseng, Chien-Te K. Barrett, Alan D. T. Ingram, Piers J. Brasel, Trevor Hanson, Brendon John The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody
author_sort	Chan, Conrad E. Z.
title	The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody
title_short	The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody
title_full	The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody
title_fullStr	The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody
title_full_unstemmed	The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody
title_sort	fc-mediated effector functions of a potent sars-cov-2 neutralizing antibody, sc31, isolated from an early convalescent covid-19 patient, are essential for the optimal therapeutic efficacy of the antibody
publisher	Public Library of Science
publishDate	2022
url	https://scholarbank.nus.edu.sg/handle/10635/232071
_version_	1781793281668022272

The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody

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