Switching Heavy Chain Constant Domains Denatures the Paratope 3D Architecture of Influenza Monoclonal Antibodies

by Malisheni, Moffat MM, Chong, Cheng-Shoong, Murali, Tanusya MM, Purushotorman, Kiren, Qian, Xinlei, Laiman, Alfred, Tan, Yee-Joo, MacAry, Paul AA
Published 2023

Defining the specificity and function of a human neutralizing antibody for Hepatitis B virus

by Jhajharia, Saket, Lai, Fritz, Low, Heng Boon, Purushotorman, Kiren, Shunmuganathan, Bhuvaneshwari Do, Chan, Conrad En Zuo, Hammond, Rachel, Netter, Hans-Juergen, Chen, Qingfeng, Lim, Seng Gee, MacAry, Paul A
Published 2023

SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets

by Raghuvamsi, Palur V, Tulsian, Nikhil K, Samsudin, Firdaus, Qian, Xinlei, Purushotorman, Kiren, Yue, Gu, Kozma, Mary M, Hwa, Wong Y, Lescar, Julien, Bond, Peter J, MacAry, Paul A, Anand, Ganesh S
Published 2021

Defining neutralization and allostery by antibodies against COVID-19 variants

by Tulsian, Nikhil Kumar, Palur, Raghuvamsi Venkata, Qian, Xinlei, Gu, Yue, Shunmuganathan, Bhuvaneshwari, Samsudin, Firdaus, Wong, Yee Hwa, Lin, Jianqing, Purushotorman, Kiren, Kozma, Mary McQueen, Wang, Bei, Lescar, Julien, Wang, Cheng-, Gupta, Ravindra Kumar, Bond, Peter John, MacAry, Paul Anthony
Published 2024

Relative deficiency in interferon-γ-secreting CD4+T cells is strongly associated with poorer COVID-19 vaccination responses in older adults

by Ho, Vanda WT, Boon, Low Heng, Cui, Jianzhou, Juequn, Zhou, Shunmuganathan, Bhuvaneshwari, Gupta, Rashi, Tan, Nikki YJ, Qian, Xinlei, Purushotorman, Kiren, Fong, Siew-Wai, Renia, Laurent, Ng, Lisa FP, Angeli, Veronique, Chen, Jinmiao, Kennedy, Brian K, Ong, Catherine WM, Macary, Paul A
Published 2024

Defining neutralization and allostery by antibodies against COVID-19 variants

by Tulsian, Nikhil Kumar, Palur, Raghuvamsi Venkata, Qian, Xinlei, Gu, Yue, Bhuvaneshwari D/O Shunmuganathan, Samsudin, Firdaus, Wong, Yee Hwa, Lin, Jianqing, Purushotorman, Kiren, Kozma, Mary McQueen, Wang, Bei, Lescar, Julien, Wang, Cheng-I, Gupta, Ravindra Kumar, Bond, Peter John, MacAry, Paul Anthony
Published 2024

Relative deficiency in interferon-γ-secreting CD4+ T cells is strongly associated with poorer COVID-19 vaccination responses in older adults

by Ho, Vanda W. T., Boon, Low Heng, Cui, Jianzhou, Juequn, Zhou, Shunmuganathan, Bhuvaneshwari, Gupta, Rashi, Tan, Nikki Y. J., Qian, Xinlei, Purushotorman, Kiren, Fong, Siew-Wai, Renia, Laurent, Ng, Lisa F. P., Angeli, Veronique, Chen, Jinmiao, Kennedy, Brian K., Ong, Catherine W. M., Macary, Paul A.
Published 2024

Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A(star)11:01

by Gu, Yue, Wong, Yee Hwa, Liew, Chong Wai, Chan, Conrad EZ, Murali, Tanusya M, Yap, Jiawei, Too, Chien Tei, Purushotorman, Kiren, Hamidinia, Maryam, El Sahili, Abbas, Goh, Angeline TH, Teo, Rachel ZC, Wood, Kathryn J, Hanson, Brendon J, Gascoigne, Nicholas RJ, Lescar, Julien, Vathsala, Anantharaman, MacAry, Paul A
Published 2021

An anti-LpqH human monoclonal antibody from an asymptomatic individual mediates protection against <i>Mycobacterium tuberculosis</i>

by Krishnananthasivam, Shivankari, Li, Hao, Bouzeyen, Rania, Shunmuganathan, Bhuvaneshwari, Purushotorman, Kiren, Liao, Xinlei, Du, Fengjiao, Friis, Claudia Guldager Kring, Crawshay-Williams, Felicity, Boon, Low Heng, Qian, Xinlei, Chan, Conrad En Zuo, Sobota, Radoslaw, Kozma, Mary, Jo, Valeria Barcelli, Wang, Guirong, Huang, Hairong, Floto, Andreas, Bifani, Pablo, Javid, Babak, Macary, Paul A
Published 2024

Author Correction: An anti-LpqH human monoclonal antibody from an asymptomatic individual mediates protection against <i>Mycobacterium tuberculosis </i>(vol 8, 136, 2023)

by Krishnananthasivam, Shivankari, Li, Hao, Bouzeyen, Rania, Shunmuganathan, Bhuvaneshwari, Purushotorman, Kiren, Liao, Xinlei, Du, Fengjiao, Friis, Claudia Guldager Kring, Crawshay-Williams, Felicity, Boon, Low Heng, Qian, Xinlei, Chan, Conrad En Zuo, Sobota, Radoslaw, Kozma, Mary, Jo, Valeria Barcelli, Wang, Guirong, Huang, Hairong, Floto, Andreas, Bifani, Pablo, Javid, Babak, Macary, Paul A
Published 2024

Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01

by Gu, Yue, Wong, Yee Hwa, Liew, Chong Wai, Chan, Conrad E. Z., Murali, Tanusya M., Yap, Jiawei, Too, Chien Tei, Purushotorman, Kiren, Hamidinia, Maryam, El Sahili, Abbas, Goh, Angeline T. H., Teo, Rachel Z. C., Wood, Kathryn J., Hanson, Brendon J., Gascoigne, Nicholas R. J., Lescar, Julien, Vathsala, Anantharaman, MacAry, Paul A.
Published 2019

Employment of a high throughput functional assay to define the critical factors that influence vaccine induced cross-variant neutralizing antibodies for SARS-CoV-2

by Gu, Yue, Shunmuganathan, Bhuvaneshwari, Qian, Xinlei, Gupta, Rashi, Tan, Rebecca S. W., Kozma, Mary, Purushotorman, Kiren, Murali, Tanusya M., Tan, Nikki Y. J., Preiser, Peter Rainer, Lescar, Julien, Nasir, Haziq, Somani, Jyoti, Tambyah, Paul A., Smith, Kenneth G. C., Renia, Laurent, Ng, Lisa F. P., Lye, David C., Young, Barnaby E., MacAry, Paul A.
Published 2024

A rapid simple point-of-care assay for the detection of SARS-CoV-2 neutralizing antibodies

by Kongsuphol, Patthara, Jia, Huan, Cheng, Hoi Lok, Gu, Yue, Shunmuganathan, Bhuvaneshwari, Chen, Ming Wei, Lim, Sing Mei, Ng, Say Yong, Tambyah, Paul Ananth, Nasir, Haziq, Gao, Xiaohong, Tay, Dousabel, Kim, Seunghyeon, Gupta, Rashi, Qian, Xinlei, Kozma, Mary M, Purushotorman, Kiren, McBee, Megan E, MacAry, Paul A, Sikes, Hadley D, Preiser, Peter R
Published 2023

The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeut...

by Chan, Conrad E. Z., Seah, Shirley G. K., Chye, De Hoe, Massey, Shane, Torres, Maricela, Lim, Angeline P. C., Wong, Steven K. K., Neo, Jacklyn J. Y., Wong, Pui San, Lim, Jie Hui, Loh, Gary S. L., Wang, Dongling, Boyd-Kirkup, Jerome D., Guan, Siyu, Thakkar, Dipti, Teo, Guo Hui, Purushotorman, Kiren, Hutchinson, Paul E., Young, Barnaby E., Low, Jenny G., MacAry, Paul A., Hentze, Hannes, Prativadibhayankara, Venkateshan S., Ethirajulu, Kantharaj, Comer, Jason E., Tseng, Chien-Te K., Barrett, Alan D. T., Ingram, Piers J., Brasel, Trevor, Hanson, Brendon John
Published 2022

Employment of a high throughput functional assay to define the critical factors that influence vaccine induced cross-variant neutralizing antibodies for SARS-CoV-2

by Gu, Yue, Shunmuganathan, Bhuvaneshwari, Qian, Xinlei, Gupta, Rashi, Tan, Rebecca SW, Kozma, Mary, Purushotorman, Kiren, Murali, Tanusya M, Tan, Nikki YJ, Preiser, Peter R, Lescar, Julien, Nasir, Haziq, Somani, Jyoti, Tambyah, Paul A, Fong, Siew-Wai, Amrun, Siti Naqiah, Goh, Yun-Shan, Tay, Matthew Zi-Rui, Rouers, Angeline, Chang, Zi Wei, Yeo, Nicholas Kim-Wah, Chan, Yi-Hao, Hor, Pei Xian, Loh, Chiew Yee, Yang, Yuling, Ruesta, Anthony Torres, Neo, Vanessa, Chen, Wendy Yehui, Goh, Estelle Yi-Wei, Ong, Alice Soh-Meoy, Chua, Adeline Chiew Yen, Nguee, Samantha, Tang, Yong Jie, Tang, Weiyi, Wong, Joel Xu En, Smith, Kenneth GC, Renia, Laurent, Ng, Lisa FP, Lye, David C, Young, Barnaby E, Macary, Paul A
Published 2024