Rapid Evaluation of Vaccine Booster Effectiveness against SARS-CoV-2 Variants

by Cheng, Hoi Lok, Lim, Sing Mei, Jia, Huan, Chen, Ming Wei, Ng, Say Yong, Gao, Xiaohong, Somani, Jyoti, Sengupta, Sharmila, Tay, Dousabel MY, Chua, Patrina WL, Abirami, R, Ling, Sharon YH, McBee, Megan E, Young, Barnaby E, Sikes, Hadley D, Preiser, Peter R
Published 2022

Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation

by Chioh, Florence WJ, Fong, Siew-Wai, Young, Barnaby E, Wu, Kan-Xing, Siau, Anthony, Krishnan, Shuba, Chan, Yi-Hao, Carissimo, Guillaume, Teo, Louis LY, Gao, Fei, Tan, Ru San, Zhong, Liang, Koh, Angela S, Tan, Seow-Yen, Tambyah, Paul A, Renia, Laurent, Ng, Lisa FP, Lye, David C, Cheung, Christine
Published 2022

Finger stick blood test to assess postvaccination SARS-CoV-2 neutralizing antibody response against variants

by Lim, Sing Mei, Cheng, Hoi Lok, Jia, Huan, Kongsuphol, Patthara, Shunmuganathan, Bhuvaneshwari, Chen, Ming Wei, Ng, Say Yong, Gao, Xiaohong, Turaga, Shuvan Prashant, Heussler, Sascha P, Somani, Jyoti, Sengupta, Sharmila, Tay, Dousabel MY, McBee, Megan E, Young, Barnaby E, MacAry, Paul A, Sikes, Hadley D, Preiser, Peter R
Published 2022

Employment of a high throughput functional assay to define the critical factors that influence vaccine induced cross-variant neutralizing antibodies for SARS-CoV-2

by Gu, Yue, Shunmuganathan, Bhuvaneshwari, Qian, Xinlei, Gupta, Rashi, Tan, Rebecca S. W., Kozma, Mary, Purushotorman, Kiren, Murali, Tanusya M., Tan, Nikki Y. J., Preiser, Peter Rainer, Lescar, Julien, Nasir, Haziq, Somani, Jyoti, Tambyah, Paul A., Smith, Kenneth G. C., Renia, Laurent, Ng, Lisa F. P., Lye, David C., Young, Barnaby E., MacAry, Paul A.
Published 2024

Oral vs Intravenous Antibiotics for Patients With Klebsiella pneumoniae Liver Abscess: A Randomized, Controlled Noninferiority Study

by Molton, James S, Chan, Monica, Kalimuddin, Shirin, Oon, Jolene, Young, Barnaby E, Low, Jenny G, Salada, Brenda MA, Lee, Tau Hong, Wijaya, Limin, Fisher, Dale A, Izharuddin, Ezlyn, Koh, Tse Hsien, Teo, Jeanette WP, Krishnan, Prabha Unny, Tan, Bien Peng, Woon, Winston WL, Ding, Ying, Wei, Yuan, Phillips, Rachel, Moorakonda, Rajesh, Yuen, Kah Hung, Cher, Boon Piang, Yoong, Joanne, Lye, David C, Archuleta, Sophia
Published 2021

Pregnancy Outcomes in COVID-19: A Prospective Cohort Study in Singapore

by Mattar, Citra Nurfarah Zaini, Kalimuddin, Shirin, Sadarangani, Sapna, Tagore, Shephali, Thain, Serene, Thoon, Koh Cheng, Hong, Eliane, Kanneganti, Abhiram, Ku, Chee Wai, Chan, Grace Mf, Lee, Kelvin Zx, Yap, Jeannie Jy, Tan, Shaun S, Yan, Benedict, Young, Barnaby E, Lye, David C, Anderson, Danielle E, Yang, Liying, Su, Lin Lin, Somani, Jyoti, Tan, Lay Kok, Choolani, Mahesh A, Chan, Jerry KY
Published 2021

Association of SARS-CoV-2 clades with clinical, inflammatory and virologic outcomes: An observational study

by Young, Barnaby E, Wei, Wycliffe E, Fong, Siew-Wai, Mak, Tze-Minn, Anderson, Danielle E, Chan, Yi-Hao, Pung, Rachael, Heng, Cheryl SY, Ang, Li Wei, Zheng, Adrian Kang Eng, Lee, Bernett, Kalimuddin, Shirin, Pada, Surinder, Tambyah, Paul A, Parthasarathy, Purnima, Tan, Seow Yen, Sun, Louisa, Smith, Gavin JD, Lin, Raymond Tzer Pin, Leo, Yee-Sin, Renia, Laurent, Wang, Lin-Fa, Ng, Lisa FP, Maurer-Stroh, Sebastian, Lye, David Chien, Lee, Vernon J
Published 2021

Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study

by Young, Barnaby E, Fong, Siew-Wai, Chan, Yi-Hao, Mak, Tze-Minn, Ang, Li Wei, Anderson, Danielle E, Lee, Cheryl Yi-Pin, Amrun, Siti Naqiah, Lee, Bernett, Goh, Yun Shan, Su, Yvonne CF, Wei, Wycliffe E, Kalimuddin, Shirin, Chai, Louis Yi Ann, Pada, Surinder, Tan, Seow Yen, Sun, Louisa, Parthasarathy, Purnima, Chen, Yuan Yi Constance, Barkham, Timothy, Lin, Raymond Tzer Pin, Maurer-Stroh, Sebastian, Leo, Yee-Sin, Wang, Lin-Fa, Renia, Laurent, Lee, Vernon J, Smith, Gavin JD, Lye, David Chien, Ng, Lisa FP
Published 2021

Viral Dynamics and Immune Correlates of Coronavirus Disease 2019 (COVID-19) Severity.

by Young, Barnaby E, Ong, Sean WX, Ng, Lisa FP, Anderson, Danielle E, Chia, Wan Ni, Chia, Po Ying, Ang, Li Wei, Mak, Tze-Minn, Kalimuddin, Shirin, Chai, Louis Yi Ann, Pada, Surinder, Tan, Seow Yen, Sun, Louisa, Parthasarathy, Purnima, Fong, Siew-Wai, Chan, Yi-Hao, Tan, Chee Wah, Lee, Bernett, Rötzschke Olaf, Ding, Ying, Tambyah, Paul, Low, Jenny GH, Cui, Lin, Barkham, Timothy, Lin, Raymond Tzer Pin, Leo, Yee-Sin, Renia, Laurent, Wang, Lin-Fa, Lye, David Chien, Singapore 2019 Novel Coronavirus Outbreak Research Team
Published 2021

The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeut...

by Chan, Conrad E. Z., Seah, Shirley G. K., Chye, De Hoe, Massey, Shane, Torres, Maricela, Lim, Angeline P. C., Wong, Steven K. K., Neo, Jacklyn J. Y., Wong, Pui San, Lim, Jie Hui, Loh, Gary S. L., Wang, Dongling, Boyd-Kirkup, Jerome D., Guan, Siyu, Thakkar, Dipti, Teo, Guo Hui, Purushotorman, Kiren, Hutchinson, Paul E., Young, Barnaby E., Low, Jenny G., MacAry, Paul A., Hentze, Hannes, Prativadibhayankara, Venkateshan S., Ethirajulu, Kantharaj, Comer, Jason E., Tseng, Chien-Te K., Barrett, Alan D. T., Ingram, Piers J., Brasel, Trevor, Hanson, Brendon John
Published 2022

A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19

by Yeo, Joo Guan, Leong, Jing Yao, Tay, Shi Huan, Nadua, Karen Donceras, Anderson, Danielle E., Lim, Amanda Jin Mei, Ng, Xiang Wen, Poh, Su Li, Guo, Dianyan, Yaung, Katherine Nay, Kumar, Pavanish, Wasser, Martin, Hazirah, Sharifah Nur, Sutamam, Nursyuhadah, Chua, Camillus Jian Hui, Qui, Martin, Foo, Randy, Gamage, Akshamal Mihiranga, Yeo, Kee Thai, Ramakrishna, Lakshmi, Arkachaisri, Thaschawee, Young, Barnaby E., Lye, David Chien, Wang, Lin-Fa, Chong, Chia Yin, Tan, Natalie Woon Hui, Li, Jiahui, Kam, Kai-Qian, Ginhoux, Florent, Thoon, Koh Cheng, Chan, Jerry Kok Yen, Yung, Chee Fu, Albani, Salvatore
Published 2022

Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals

by Lim, Jackwee, Puan, Kia Joo, Wang, Liang Wei, Teng, Karen Wei Weng, Loh, Chiew Yee, Tan, Kim Peng, Carissimo, Guillaume, Chan, Yi-Hao, Poh, Chek Meng, Lee, Cheryl Yi-Pin, Fong, Siew-Wai, Yeo, Nicholas Kim-Wah, Chee, Rhonda Sin-Ling, Amrun, Siti Naqiah, Chang, Zi Wei, Tay, Matthew Zirui, Torres-Ruesta, Anthony, Leo Fernandez, Norman, How, Wilson, Andiappan, Anand Kumar, Lee, Wendy, Duan, Kaibo, Tan, Seow-Yen, Yan, Gabriel, Kalimuddin, Shirin, Lye, David Chien, Leo, Yee-Sin, Ong, Sean W. X., Young, Barnaby E., Renia, Laurent, Ng, Lisa F. P., Lee, Bernett, Rötzschke, Olaf
Published 2022

Efficient recall of SARS-CoV-2 variant-reactive B cells and T responses in the elderly upon heterologous mRNA vaccines as boosters

by Rouers, Angeline, Wong, Nathan, Goh, Yun Shan, Torres-Ruesta, Anthony, Tay, Matthew Zirui, Chang, Zi Wei, Fong, Siew-Wai, Neo, Vanessa, Kam, Isaac Kai Jie, Yeo, Nicholas Kim-Wah, Huang, Yuling, Loh, Chiew Yee, Hor, Pei Xiang, Wong, Joel Xu En, Tan, Yong Jie, Macary, Paul A, Qian, Xinlei, Wang Bei, Ngoh, Eve Zi Xian, Salleh, Siti Nazihah Mohd, Wang, Cheng-, Poh, Xuan Ying, Rao, Suma, Chia, Po Ying, Ong, Sean WX, Lee, Tau Hong, Lin, Ray JH, Lim, Clarissa, Teo, Jefanie, Ren, Ee Chee, Lye, David Chien, Young, Barnaby E, Ng, Lisa FP, Renia, Laurent
Published 2023

Employment of a high throughput functional assay to define the critical factors that influence vaccine induced cross-variant neutralizing antibodies for SARS-CoV-2

by Gu, Yue, Shunmuganathan, Bhuvaneshwari, Qian, Xinlei, Gupta, Rashi, Tan, Rebecca SW, Kozma, Mary, Purushotorman, Kiren, Murali, Tanusya M, Tan, Nikki YJ, Preiser, Peter R, Lescar, Julien, Nasir, Haziq, Somani, Jyoti, Tambyah, Paul A, Fong, Siew-Wai, Amrun, Siti Naqiah, Goh, Yun-Shan, Tay, Matthew Zi-Rui, Rouers, Angeline, Chang, Zi Wei, Yeo, Nicholas Kim-Wah, Chan, Yi-Hao, Hor, Pei Xian, Loh, Chiew Yee, Yang, Yuling, Ruesta, Anthony Torres, Neo, Vanessa, Chen, Wendy Yehui, Goh, Estelle Yi-Wei, Ong, Alice Soh-Meoy, Chua, Adeline Chiew Yen, Nguee, Samantha, Tang, Yong Jie, Tang, Weiyi, Wong, Joel Xu En, Smith, Kenneth GC, Renia, Laurent, Ng, Lisa FP, Lye, David C, Young, Barnaby E, Macary, Paul A
Published 2024

Effect of Vancomycin or Daptomycin With vs Without an Antistaphylococcal beta-Lactam on Mortality, Bacteremia, Relapse, or Treatment Failure in Patients With MRSA Bacteremia A Rand...

by Tong, Steven YC, Lye, David C, Yahav, Dafna, Sud, Archana, Robinson, J Owen, Nelson, Jane, Archuleta, Sophia, Roberts, Matthew A, Cass, Alan, Paterson, David L, Foo, Hong, Paul, Mical, Guy, Stephen D, Tramontana, Adrian R, Walls, Genevieve B, McBride, Stephen, Bak, Narin, Ghosh, Niladri, Rogers, Benjamin A, Ralph, Anna P, Davies, Jane, Ferguson, Patricia E, Dotel, Ravindra, McKew, Genevieve L, Gray, Timothy J, Holmes, Natasha E, Smith, Simon, Warner, Morgyn S, Kalimuddin, Shirin, Young, Barnaby E, Runnegar, Naomi, Andresen, David N, Anagnostou, Nicholas A, Johnson, Sandra A, Chatfield, Mark D, Cheng, Allen C, Fowler, Vance G, Howden, Benjamin P, Meagher, Niamh, Price, David J, van Hal, Sebastiaan J, O'Sullivan, Matthew VN, Davis, Joshua S
Published 2022