Blocking aerobic glycolysis by targeting pyruvate dehydrogenase kinase in combination with egfr tki and ionizing radiation increases therapeutic effect in non-small cell lung cancer cells

Blocking aerobic glycolysis by targeting pyruvate dehydrogenase kinase in combination with egfr tki and ionizing radiation increases therapeutic effect in non-small cell lung cancer cells

10.3390/cancers13050941

Saved in:

Bibliographic Details
Main Authors:	Dyrstad, Sissel E., Lotsberg, Maria L., Tan, Tuan Zea, Pettersen, Ina K. N., Hjellbrekke, Silje, Tusubira, Deusdedit, Engelsen, Agnete S. T., Daubon, Thomas, Mourier, Arnaud, Thiery, Jean Paul, Dahl, Olav, Lorens, James B., Tronstad, Karl Johan, Røsland, G.V.
Other Authors:	CANCER SCIENCE INSTITUTE OF SINGAPORE
Format:	Article
Published:	MDPI AG 2022
Subjects:	DCA EGFR TKI Glycolysis Ionizing radiation Mitochondria NSCLC PDH PDHK Warburg effect
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/233232
Tags:	Add Tag No Tags, Be the first to tag this record!
Institution:	National University of Singapore

Similar Items

TARGETING THE PIK3 PATHWAY IN NON-SMALL CELL LUNG CANCER
by: DANIEL TAN SHAO WENG
Published: (2017)

Real world efficacy of osimertinib in second line/beyond in patients with metastatic EGFR plus non-small cell lung cancer and role of paired tumour-plasma T790M testing at tyrosine kinase inhibitor resistance
by: Ma, Jun, et al.
Published: (2024)

Inhibiting proliferation of gefitinib-resistant, non-small cell lung cancer
by: Sudo, M., et al.
Published: (2014)

Performance of channel carrying for handoff in a DCA cellular network
by: Jiang, S., et al.
Published: (2014)

Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism
by: Thangavelu, K., et al.
Published: (2014)

EXPLORING TARGETED AND NON-TARGETED APPROACHES IN THE DEVELOPMENT OF ANTI-FIBROTIC THERAPY FOR LIVER FIBROSIS
by: SOH KAR LING CARRIE
Published: (2017)

STRUCTURAL AND FUNCTIONAL BASIS OF GLUTAMINASE AS A NOVEL TARGET FOR ARRESTING CANCER CELLS METABOLISM
by: THANGAVELU K
Published: (2013)

Discovering novel SNPs that are correlated with patient outcome in a Singaporean cancer patient cohort treated with gemcitabine-based chemotherapy
by: Limviphuvadh, Vachiranee, et al.
Published: (2018)

CHARACTERIZING CISPLATIN-RESISTANT NSCLC CELLS AND IDENTIFYING TRAIL AS A POTENTIAL SECOND-LINE THERAPY IN REFRACTORY CANCER CELLS
by: SEAH BEE KEE SERENA
Published: (2013)

Clinical and testing protocols for the analysis of epidermal growth factor receptor mutations in East Asian patients with non-small cell lung cancer: A combined clinical-molecular pathological approach
by: Salto-Tellez, M., et al.
Published: (2014)

The role of Prion Protein in Breast Cancer cell metabolism
by: WONG HUIMIN IRA
Published: (2013)

SRSF1-MEDIATED TYROSINE KINASE INHIBITOR RESISTANCE IN CHRONIC MYELOID LEUKAEMIA
by: SINNAKANNU JOANNA RAJESWARY
Published: (2018)

Extracellular citrate and metabolic adaptations of cancer cells
by: Parkinson, E. Kenneth, et al.
Published: (2022)

Targeting the mitochondrial pyruvate carrier for neuroprotection
by: Tang, B.L.
Published: (2021)

ELUCIDATING TUMOR SUPPRESSIVE FUNCTION OF FRATAXIN IN COLORECTAL CANCER WITH A QUANTITATIVE PROTEOMICS APPROACH
by: TAN XING FEI
Published: (2014)

The IκB kinase inhibitor ACHP targets the STAT3 signaling pathway in human non-small cell lung carcinoma cells
by: Lee, J.H., et al.
Published: (2021)

Phase 2 trial of linifanib (ABT-869) in patients with advanced non-small cell lung cancer
by: Tan, E.-H., et al.
Published: (2014)

Thromboembolism in ALK+ and ROS1+ NSCLC patients: A systematic review and meta-analysis
by: Zhu, Viola W., et al.
Published: (2022)

REGULATION OF AMPK ACTIVATION AND ITS ROLE IN CELL DEATH INDUCED BY GLUCOSE STARVATION IN LKB1-MUTANT HUMAN LUNG CANCER CELLS
by: REN YI
Published: (2019)

Aspirin potentiates celecoxib-induced growth inhibition and apoptosis in human non-small cell lung cancer by targeting GRP78 activity
by: Zhang, X., et al.
Published: (2021)

Targeting microtubules sensitizes drug resistant lung cancer cells to lysosomal pathway inhibitors
by: Chin, T.-M., et al.
Published: (2021)

Differences in outcome and toxicity between Asian and caucasian patients with lung cancer treated with systemic therapy
by: Soo, R.A., et al.
Published: (2014)

CAV1 - GLUT3 signaling is important for cellular energy and can be targeted by Atorvastatin in Non-Small Cell Lung Cancer
by: Ali, A., et al.
Published: (2022)

Long-term prognostic significance of interleukin-17-producing T cells in patients with non-small cell lung cancer
by: Song, L., et al.
Published: (2021)

Cost-effectiveness analysis of egfr mutation testing and afatinib versus gemcitabine-cisplatin as first-line therapy for advanced non-small-cell lung cancer in china
by: You, R., et al.
Published: (2021)

INSIGHT INTO THE BIOENERGETICS OF CLEAR CELL RENAL CELL CARCINOMA (CCRCC)
by: LIM HWEE YING
Published: (2014)

Role of glycolysis in myeloid cells during dengue infection
by: Loy, Thomas
Published: (2022)

Phát hiện đột biến T790M thứ phát trên gen EGFR ở bệnh nhân ung thư phổi không tế bào nhỏ kháng thuốc điều trị đích
by: Trần, Quốc Đạt, et al.
Published: (2020)

Brief Report: Droplet Digital Polymerase Chain Reaction Versus Plasma Next-Generation Sequencing in Detecting Clearance of Plasma EGFR Mutations and Carcinoembryonic Antigen Levels as a Surrogate Measure
by: Saw, Stephanie PL, et al.
Published: (2024)

MED13 and glycolysis are conserved modifiers of α-synuclein-associated neurodegeneration
by: Ren, Mengda, et al.
Published: (2023)

Power to see—Drivers of aerobic glycolysis in the mammalian retina: A review
by: Cameron D. Haydinger, et al.
Published: (2020)

Targeting Glycolysis in Macrophages Confers Protection Against Pancreatic Ductal Adenocarcinoma
by: Penny, Hweixian Leong, et al.
Published: (2021)

First-line afatinib for the treatment of EGFR mutation-positive non-small-cell lung cancer in the 'real-world' clinical setting
by: Park, Keunchil, et al.
Published: (2022)

A meta-analysis on immune checkpoint inhibitor efficacy for advanced non-small cell lung cancer between East Asians versus non-East Asians
by: Peng, S., et al.
Published: (2021)

CEREBRAL ANAEROBIC GLYCOLYSIS AND REDUCED CEREBRAL OXYGEN TRANSPORT IN HUMAN CEREBRAL MALARIA
by: D. A. Warrell, et al.
Published: (2018)

Increased Akt-Driven Glycolysis Is the Basis for the Higher Potency of CD137L-DCs
by: Zeng, Q, et al.
Published: (2019)

Randomized controlled trial of S-1 versus docetaxel in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy (East Asia S-1 Trial in Lung Cancer)
by: Nokihara, H, et al.
Published: (2022)

Effective catalysts derived from waste ostrich eggshells for glycolysis of post-consumer PET bottles
by: Isti Yunita, et al.
Published: (2020)

Partial Substitution of Glucose with Xylitol Suppressed the Glycolysis and Selectively Inhibited the Proliferation of Oral Cancer Cells
by: Dunyaporn Trachootham, et al.
Published: (2018)

Experience from Asian centers in a named-patient-use program for afatinib in patients with advanced non-small-cell lung cancer who had progressed following prior therapies, including patients with uncommon EGFR mutations
by: Chang, Gee-Chen, et al.
Published: (2022)