Emodin Suppresses Migration and Invasion through the Modulation of CXCR4 Expression in an Orthotopic Model of Human Hepatocellular Carcinoma

Emodin Suppresses Migration and Invasion through the Modulation of CXCR4 Expression in an Orthotopic Model of Human Hepatocellular Carcinoma

10.1371/journal.pone.0057015

Saved in:

Bibliographic Details
Main Authors:	Manu, K.A., Shanmugam, M.K., Ong, T.H., Subramaniam, A., Siveen, K.S., Perumal, E., Samy, R.P., Bist, P., Lim, L.H.K., Kumar, A.P., Hui, K.M., Sethi, G.
Other Authors:	CANCER SCIENCE INSTITUTE OF SINGAPORE
Format:	Article
Published:	2014
Online Access:	http://scholarbank.nus.edu.sg/handle/10635/52904
Tags:	Add Tag No Tags, Be the first to tag this record!
Institution:	National University of Singapore

Similar Items

Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3
by: Subramaniam, A., et al.
Published: (2014)

An anthraquinone derivative, emodin sensitizes hepatocellular carcinoma cells to TRAIL induced apoptosis through the induction of death receptors and downregulation of cell survival proteins
by: Subramaniam, A., et al.
Published: (2014)

Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model
by: Shanmugam, M.K., et al.
Published: (2014)

Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-κB activation in breast and pancreatic tumor cells
by: Chua, A.W.L., et al.
Published: (2014)

?-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model
by: Siveen K.S., et al.
Published: (2020)

γ-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model
by: Siveen, K.S., et al.
Published: (2014)

Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4
by: Manu, K.A., et al.
Published: (2014)

Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B-regulated gene products
by: Manu, K.A., et al.
Published: (2014)

Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer
by: Shrimali, D., et al.
Published: (2014)

Preclinical evaluation of transcriptional targeting strategy for human hepatocellular carcinoma in an orthotopic xenograft mouse model
by: Sia, K.C., et al.
Published: (2014)

γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: Potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent
by: Rajendran, P., et al.
Published: (2014)

Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo
by: Sethi, G., et al.
Published: (2014)

Suppression of signal transducer and activator of transcription 3 activation by butein inhibits growth of human hepatocellular carcinoma in vivo
by: Rajendran, P., et al.
Published: (2014)

AZD6244 enhances the anti-tumor activity of sorafenib in ectopic and orthotopic models of human hepatocellular carcinoma (HCC)
by: Huynh, H, et al.
Published: (2011)

Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways
by: Kannaiyan, R., et al.
Published: (2014)

Potential role of signal transducer and activator of transcription (STAT)3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinoma
by: Subramaniam, A., et al.
Published: (2014)

Identification of matrine as a novel regulator of the CXCR4 signaling axis in tumor cells
by: Jung, Y.Y., et al.
Published: (2021)

Inhibitory effect of emodin on tumor invasion through suppression of activator protein-1 and nuclear factor-κB
by: Huang, Q., et al.
Published: (2014)

Expression pattern of two zebrafish genes, cxcr4a and cxcr4b
by: Chong, S.W., et al.
Published: (2014)

Dysregulation of Nrf2 in hepatocellular carcinoma: Role in cancer progression and chemoresistance
by: Raghunath, A., et al.
Published: (2021)

Bevacizumab and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma
by: Huynh, H., et al.
Published: (2012)

Bevacizumab and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma
by: Huynh, H., et al.
Published: (2011)

Emodin inhibits tumor cell migration through suppression of the phosphatidylinositol 3-kinase-Cdc42/Rac1 pathway
by: Huang, Q., et al.
Published: (2014)

AZD6244 and doxorubicin induce growth suppression and apoptosis in mouse models of hepatocellular carcinoma
by: Huynh, H, et al.
Published: (2020)

Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells
by: Li, F., et al.
Published: (2011)

Brusatol suppresses STAT3-driven metastasis by downregulating epithelial-mesenchymal transition in hepatocellular carcinoma
by: Lee, J.H., et al.
Published: (2021)

Celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade In Vitro and In Vivo
by: Rajendran, P., et al.
Published: (2014)

Celastrol attenuates the invasion and migration and augments the anticancer effects of bortezomib in a xenograft mouse model of multiple myeloma
by: Shanmugam, M.K, et al.
Published: (2020)

Identification of β-escin as a novel inhibitor of signal transducer and activator of transcription 3/janus-activated kinase 2 signaling pathway that suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells
by: Tan, S.M.-L., et al.
Published: (2011)

Identification of a Novel Calotropis procera Protein That Can Suppress Tumor Growth in Breast Cancer through the Suppression of NF-κB Pathway
by: Samy, R.P., et al.
Published: (2014)

Melioidosis: Clinical impact and public health threat in the tropics
by: Perumal Samy R., et al.
Published: (2020)

Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1
by: Rajendran, P., et al.
Published: (2014)

Nonviral cytokine gene therapy on an orthotopic bladder cancer model
by: Wu, Q., et al.
Published: (2011)

Identification of proteins differentially expressed between capillary endothelial cells of hepatocellular carcinoma and normal liver in an orthotopic rat tumor model using 2-D DIGE
by: Jia, J., et al.
Published: (2014)

Suppression of essential pro-inflammatory signaling pathways by natural agents for the therapy of multiple myeloma
by: Sikka, S., et al.
Published: (2014)

ANXA1 inhibits miRNA-196a in a negative feedback loop through NF-kB and C-Myc to reduce breast cancer proliferation
by: Yuan, Y, et al.
Published: (2020)

Tumor and microenvironment modification during progression of murine orthotopic bladder cancer
by: Tham, S.M., et al.
Published: (2014)

A murine orthotopic bladder tumor model and tumor detection system
by: Tham S.M., et al.
Published: (2018)

Mekanisme dan kinetika kuesing aloe emodin terhadap fotooksidasi asam linoleat=Quenching Mechanism and Kinetics of Aloe Emodin in Linoleic Acid Photooxidation
by: Perpustakaan UGM, i-lib
Published: (2006)

Silencing of connexin 43 suppresses invasion, migration and lung metastasis of rat hepatocellular carcinoma cells
by: Ogawa K., et al.
Published: (2014)