The influence of pH on the G-quadruplex binding selectivity of perylene derivatives
Three new perylene derivatives with branched ionizable side chains were synthesized, and their G-quadruplex binding specificities were compared by spectroscopic and electrophoretic analysis with two well-studied G-quadruplex ligands: PIPER and TmPyP4. The value of pH and consequent charge formation...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2014
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| Online Access: | http://www.scopus.com/inward/record.url?eid=2-s2.0-33745141952&partnerID=40&md5=16a2df1db67a778619993a7da18008a2 http://www.ncbi.nlm.nih.gov/pubmed/16713263 http://cmuir.cmu.ac.th/handle/6653943832/2062 |
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| Institution: | Chiang Mai University |
| Language: | English |
| Summary: | Three new perylene derivatives with branched ionizable side chains were synthesized, and their G-quadruplex binding specificities were compared by spectroscopic and electrophoretic analysis with two well-studied G-quadruplex ligands: PIPER and TmPyP4. The value of pH and consequent charge formation and self-aggregation of these perylene derivatives influences not only the type of G-quadruplex formation, but also the G-quadruplex binding selectivity. © 2006 Elsevier Ltd. All rights reserved. |
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