Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis

• Main Authors: Sriburi R., Bommiasamy H., Buldak G.L., Robbins G.R., Frank M., Jackowski S., Brewer J.W.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-34147172715&partnerID=40&md5=ba0a6da33929eb5c21cac773db391194; http://cmuir.cmu.ac.th/handle/6653943832/2241
• Institution: Chiang Mai University

Development of the expansive endoplasmic reticulum (ER) present in specialized secretory cell types requires X-box-binding protein-1 (Xbp-1). Enforced expression of XBP-1(S), a transcriptional activator generated by unfolded protein response-mediated splicing of Xbp-1 mRNA, is sufficient to induce p...