Kuguacin J isolated from Momordica charantia leaves inhibits P-glycoprotein (ABCB1)-mediated multidrug resistance

• Main Authors: Pitchakarn P., Ohnuma S., Pintha K., Pompimon W., Ambudkar S.V., Limtrakul P.
• 格式: Article
• 語言: English
• 出版: 2014
• 在線閱讀: http://www.scopus.com/inward/record.url?eid=2-s2.0-83355172162&partnerID=40&md5=ea0d81fab8097b08a618fea769370b4a; http://www.ncbi.nlm.nih.gov/pubmed/21414769; http://cmuir.cmu.ac.th/handle/6653943832/2683

Multidrug resistance (MDR) is a major factor in the failure of chemotherapy in cancer patients. Resistance to chemotherapy has been correlated to the overexpression of ABC drug transporters including P-glycoprotein (P-gp) that actively efflux chemotherapeutic drugs from cancer cells. Our previous st...