Reversal of cardiac iron loading and dysfunction in thalassemic mice by curcuminoids

• Main Authors: Thephinlap C., Phisalaphong C., Lailerd N., Chattipakorn N., Winichagoon P., Vadolus J., Fucharoen S., Porter J.B., Srichairatanakool S.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-78751479300&partnerID=40&md5=784a8d5e002348796d4084e9c4dc0243; http://www.ncbi.nlm.nih.gov/pubmed/21235521; http://cmuir.cmu.ac.th/handle/6653943832/2723
• Institution: Chiang Mai University

Non-transferrin bound iron (NTBI) is found in plasma of β-thalassemia patients and causes oxidative tissue damage. Cardiac siderosis and complications are the secondary cause of death in β-thalassemia major patients. Desferrioxamine (DFO), deferiprone (DFP) and deferasirox (DFX) are promising chelat...