Antiproliferative effects of cucurbitacin B in breast cancer cells: Down-regulation of the c-Myc/hTERT/telomerase pathway and obstruction of the cell cycle

• Main Authors: Duangmano,S., Dakeng,S., Jiratchariyakul,W., Suksamrarn,A., Smith,D.R., Patmasiriwat,P.
• Format: Article
• Published: Multidisciplinary Digital Publishing Institute (MDPI) 2015
• Subjects: Catalysis; Computer Science Applications; Spectroscopy; Organic Chemistry; Molecular Biology; Physical and Theoretical Chemistry; Inorganic Chemistry
• Online Access: http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=78650985401&origin=inward; http://cmuir.cmu.ac.th/handle/6653943832/38090
• Institution: Chiang Mai University

Naturally occurring cucurbitacins have been shown to have anticancer, antimicrobial and anti-inflammatory activities. In this study, we determined the effects of cucurbitacin B extracted from the Thai herb Trichosanthes cucumerina L. on telomerase regulation in three human breast cancer cell lines (...