Telomere shortening and cell senescence induced by perylene derivatives in A549 human lung cancer cells

• Main Authors: Taka T., Huang L., Wongnoppavich A., Tam-Chang S.-W., Lee T.R., Tuntiwechapikul W.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-84873312526&partnerID=40&md5=b55d40a92e31ccb4ff50cacfcac3b9c2; http://www.ncbi.nlm.nih.gov/pubmed/23321015; http://cmuir.cmu.ac.th/handle/6653943832/4017
• Institution: Chiang Mai University

Cancer cells evade replicative senescence by re-expressing telomerase, which maintains telomere length and hence chromosomal integrity. Telomerase inhibition would lead cancer cells to senesce and therefore prevent cancer cells from growing indefinitely. G-quadruplex ligands can attenuate telomerase...