Telomere shortening and cell senescence induced by perylene derivatives in A549 human lung cancer cells

Cancer cells evade replicative senescence by re-expressing telomerase, which maintains telomere length and hence chromosomal integrity. Telomerase inhibition would lead cancer cells to senesce and therefore prevent cancer cells from growing indefinitely. G-quadruplex ligands can attenuate telomerase...

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Bibliographic Details
Main Authors: Taka T., Huang L., Wongnoppavich A., Tam-Chang S.-W., Lee T.R., Tuntiwechapikul W.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-84873312526&partnerID=40&md5=b55d40a92e31ccb4ff50cacfcac3b9c2
http://www.ncbi.nlm.nih.gov/pubmed/23321015
http://cmuir.cmu.ac.th/handle/6653943832/4017
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Institution: Chiang Mai University
Language: English

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