Physiologically based pharmacokinetic model of mechanism-based inhibition of CYP3A by clarithromycin

The prediction of clinical drug-drug interactions (DDIs) due to mechanism-based inhibitors of CYP3A is complicated when the inhibitor itself is metabolized by CYP3A, as in the case of clarithromycin. Previous attempts to predict the effects of clarithromycin on CYP3A substrates, e.g., midazolam, fai...

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Bibliographic Details
Main Authors: Quinney S.K., Zhang X., Lucksiri A., Gorski J.C., Li L., Hall S.D.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-76149083862&partnerID=40&md5=474c87e21322e9d8b54c62945acb791f
http://cmuir.cmu.ac.th/handle/6653943832/4621
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Institution: Chiang Mai University
Language: English

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