A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents

A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents

Most anticancer drugs have their origin in traditional medicinal plants. We describe here a flavone, 5,3′-dihydroxy-3,6,7,8,4′- pentamethoxyflavone (PMF), from the leaves of the Thai plant Gardenia obtusifolia, that has anti-inflammatory and anticancer potential. Because the nuclear factor-κB (NF-κB...

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書目詳細資料
Main Authors:	Kanokkarn Phromnoi, Simone Reuter, Bokyung Sung, Sahdeo Prasad, Ramaswamy Kannappan, Vivek R. Yadav, Wisinee Chanmahasathien, Pornngarm Limtrakul, Bharat B. Aggarwal
格式:	雜誌
出版:	2018
主題:	Biochemistry, Genetics and Molecular Biology Pharmacology, Toxicology and Pharmaceutics
在線閱讀:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78751533767&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/49739
標簽:	添加標簽沒有標簽, 成為第一個標記此記錄!
機構:	Chiang Mai University

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