A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents

• Main Authors: Kanokkarn Phromnoi, Simone Reuter, Bokyung Sung, Sahdeo Prasad, Ramaswamy Kannappan, Vivek R. Yadav, Wisinee Chanmahasathien, Pornngarm Limtrakul, Bharat B. Aggarwal
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78751533767&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/49739
• Institution: Chiang Mai University

Most anticancer drugs have their origin in traditional medicinal plants. We describe here a flavone, 5,3′-dihydroxy-3,6,7,8,4′- pentamethoxyflavone (PMF), from the leaves of the Thai plant Gardenia obtusifolia, that has anti-inflammatory and anticancer potential. Because the nuclear factor-κB (NF-κB...