Physiologically based pharmacokinetic model of mechanism-based inhibition of CYP3A by clarithromycin
The prediction of clinical drug-drug interactions (DDIs) due to mechanism-based inhibitors of CYP3A is complicated when the inhibitor itself is metabolized by CYP3A, as in the case of clarithromycin. Previous attempts to predict the effects of clarithromycin on CYP3A substrates, e.g., midazolam, fai...
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| Main Authors: | , , , , , |
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| Format: | Journal |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=76149083862&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51156 |
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| Institution: | Chiang Mai University |