Zinc finger protein designed to target 2-long terminal repeat junctions interferes with human immunodeficiency virus integration

• Main Authors: Supachai Sakkhachornphop, Carlos F. Barbas, Rassamee Keawvichit, Kanlaya Wongworapat, Chatchai Tayapiwatana
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84866325679&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/51361
• Institution: Chiang Mai University

Integration of the human immunodeficiency virus type 1 (HIV-1) genome into the host chromosome is a vital step in the HIV life cycle. The highly conserved cytosine-adenine (CA) dinucleotide sequence immediately upstream of the cleavage site is crucial for integrase (IN) activity. As this viral enzym...