A combination of an iron chelator with an antioxidant effectively diminishes the dendritic loss, tau-hyperphosphorylation, amyloids-β accumulation and brain mitochondrial dynamic disruption in rats with chronic iron-overload
© 2016 IBRO Iron-overload can cause cognitive impairment due to blood–brain barrier (BBB) breakdown and brain mitochondrial dysfunction. Although deferiprone (DFP) has been shown to exert neuroprotection, the head-to-head comparison among iron chelators used clinically on brain iron-overload has not...
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Main Authors: | Jirapas Sripetchwandee, Suwakon Wongjaikam, Warunsorn Krintratun, Nipon Chattipakorn, Siriporn C. Chattipakorn |
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Format: | Journal |
Published: |
2018
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Subjects: | |
Online Access: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84978715654&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/56256 |
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Institution: | Chiang Mai University |
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