HCV induces transforming growth factor β1 through activation of endoplasmic reticulum stress and the unfolded protein response

• Main Authors: Pattranuch Chusri, Kattareeya Kumthip, Jian Hong, Chuanlong Zhu, Xiaoqiong Duan, Nikolaus Jilg, Dahlene N. Fusco, Cynthia Brisac, Esperance A. Schaefer, Dachuan Cai, Lee F. Peng, Niwat Maneekarn, Wenyu Lin, Raymond T. Chung
• Format: Journal
• Published: 2018
• Subjects: Multidisciplinary
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84959467728&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/56372
• Institution: Chiang Mai University

HCV replication disrupts normal endoplasmic reticulum (ER) function and activates a signaling network called the unfolded protein response (UPR). UPR is directed by three ER transmembrane proteins including ATF6, IRE1, and PERK. HCV increases TGF-β1 and oxidative stress, which play important roles i...