Chemo-enzymatic synthesis of (-)-epipentenomycin I

• Main Authors: Klomklao T., Pyne S.G., Baramee A., Skelton B.W., White A.H.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-0345059173&partnerID=40&md5=1da59e04454926469f369041bd5c341b; http://cmuir.cmu.ac.th/handle/6653943832/5681
• Institution: Chiang Mai University

A chemo-enzymatic synthesis of (-)-epipentenomycin I is reported using a lipase-catalysed kinetic resolution of the racemic pentacyclic alcohol 8. Flash vacuum pyroloysis of (-)-8 so obtained gave (-)-(4R)-4-hydroxy-5-methylene-2- cyclopentenone. Epoxidation of this compound with dimethyldioxirane f...