Chemo-enzymatic synthesis of (-)-epipentenomycin I
A chemo-enzymatic synthesis of (-)-epipentenomycin I is reported using a lipase-catalysed kinetic resolution of the racemic pentacyclic alcohol 8. Flash vacuum pyroloysis of (-)-8 so obtained gave (-)-(4R)-4-hydroxy-5-methylene-2- cyclopentenone. Epoxidation of this compound with dimethyldioxirane f...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2014
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| Online Access: | http://www.scopus.com/inward/record.url?eid=2-s2.0-0345059173&partnerID=40&md5=1da59e04454926469f369041bd5c341b http://cmuir.cmu.ac.th/handle/6653943832/5681 |
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| Institution: | Chiang Mai University |
| Language: | English |
| Summary: | A chemo-enzymatic synthesis of (-)-epipentenomycin I is reported using a lipase-catalysed kinetic resolution of the racemic pentacyclic alcohol 8. Flash vacuum pyroloysis of (-)-8 so obtained gave (-)-(4R)-4-hydroxy-5-methylene-2- cyclopentenone. Epoxidation of this compound with dimethyldioxirane followed by hydrolytic ring-opening of the resulting epoxide gave (-)-epipentenomycin I. © 2003 Elsevier Ltd. All rights reserved. |
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