Epigallocatechin-3-gallate and epicatechin-3-gallate from green tea decrease plasma non-transferrin bound iron and erythrocyte oxidative stress

β-Thalassemia patients suffer from secondary iron overload caused by increased iron absorption and multiple blood transfusions. Excessive iron catalyzes free-radical formation, causing oxidative tissue damage. Non-transferrin bound iron (NTBI) detected in thalassemic plasma is highly toxic and chela...

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Main Authors: C. Thephinlap, S. Ounjaijean, U. Khansuwan, S. Fucharoen, J. B. Porter, S. Srichairatanakool
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/61377
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-613772018-09-10T04:09:40Z Epigallocatechin-3-gallate and epicatechin-3-gallate from green tea decrease plasma non-transferrin bound iron and erythrocyte oxidative stress C. Thephinlap S. Ounjaijean U. Khansuwan S. Fucharoen J. B. Porter S. Srichairatanakool Pharmacology, Toxicology and Pharmaceutics β-Thalassemia patients suffer from secondary iron overload caused by increased iron absorption and multiple blood transfusions. Excessive iron catalyzes free-radical formation, causing oxidative tissue damage. Non-transferrin bound iron (NTBI) detected in thalassemic plasma is highly toxic and chelatable. Desferrioxamine and deferiprone are used to treat the iron overload, but many side effects are found. Epigallocatechin gallate (EGCG) and epicatechin gallate (ECG) in green tea (GT) show strong antioxidant properties. We separated the EGCG and ECG from GT extract using an HPLC, and examined their iron-binding and free-radical scavenging activities. They bound Fe3+ rapidly to form a complex with a predominant absorption at 560 mn. EGCG and ECG bound chemical Fe3+ and chelated the NTBI in a time- and dose dependent manner. They also decreased oxidative stress in iron-treated erythrocytes. In conclusion, EGCG and ECG could be natural iron chelators that efficiently decrease the levels of NTBI and free radicals in iron overload. © 2007 Bentham Science Publishers Ltd. 2018-09-10T04:09:40Z 2018-09-10T04:09:40Z 2007-05-01 Journal 15734064 2-s2.0-34248657988 10.2174/157340607780620608 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34248657988&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/61377
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Pharmacology, Toxicology and Pharmaceutics
spellingShingle Pharmacology, Toxicology and Pharmaceutics
C. Thephinlap
S. Ounjaijean
U. Khansuwan
S. Fucharoen
J. B. Porter
S. Srichairatanakool
Epigallocatechin-3-gallate and epicatechin-3-gallate from green tea decrease plasma non-transferrin bound iron and erythrocyte oxidative stress
description β-Thalassemia patients suffer from secondary iron overload caused by increased iron absorption and multiple blood transfusions. Excessive iron catalyzes free-radical formation, causing oxidative tissue damage. Non-transferrin bound iron (NTBI) detected in thalassemic plasma is highly toxic and chelatable. Desferrioxamine and deferiprone are used to treat the iron overload, but many side effects are found. Epigallocatechin gallate (EGCG) and epicatechin gallate (ECG) in green tea (GT) show strong antioxidant properties. We separated the EGCG and ECG from GT extract using an HPLC, and examined their iron-binding and free-radical scavenging activities. They bound Fe3+ rapidly to form a complex with a predominant absorption at 560 mn. EGCG and ECG bound chemical Fe3+ and chelated the NTBI in a time- and dose dependent manner. They also decreased oxidative stress in iron-treated erythrocytes. In conclusion, EGCG and ECG could be natural iron chelators that efficiently decrease the levels of NTBI and free radicals in iron overload. © 2007 Bentham Science Publishers Ltd.
format Journal
author C. Thephinlap
S. Ounjaijean
U. Khansuwan
S. Fucharoen
J. B. Porter
S. Srichairatanakool
author_facet C. Thephinlap
S. Ounjaijean
U. Khansuwan
S. Fucharoen
J. B. Porter
S. Srichairatanakool
author_sort C. Thephinlap
title Epigallocatechin-3-gallate and epicatechin-3-gallate from green tea decrease plasma non-transferrin bound iron and erythrocyte oxidative stress
title_short Epigallocatechin-3-gallate and epicatechin-3-gallate from green tea decrease plasma non-transferrin bound iron and erythrocyte oxidative stress
title_full Epigallocatechin-3-gallate and epicatechin-3-gallate from green tea decrease plasma non-transferrin bound iron and erythrocyte oxidative stress
title_fullStr Epigallocatechin-3-gallate and epicatechin-3-gallate from green tea decrease plasma non-transferrin bound iron and erythrocyte oxidative stress
title_full_unstemmed Epigallocatechin-3-gallate and epicatechin-3-gallate from green tea decrease plasma non-transferrin bound iron and erythrocyte oxidative stress
title_sort epigallocatechin-3-gallate and epicatechin-3-gallate from green tea decrease plasma non-transferrin bound iron and erythrocyte oxidative stress
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34248657988&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/61377
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