The influence of pH on the G-quadruplex binding selectivity of perylene derivatives

Three new perylene derivatives with branched ionizable side chains were synthesized, and their G-quadruplex binding specificities were compared by spectroscopic and electrophoretic analysis with two well-studied G-quadruplex ligands: PIPER and TmPyP4. The value of pH and consequent charge formation...

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Main Authors:	Wirote Tuntiwechapikul, Thanachai Taka, Mathilde Béthencourt, Luksana Makonkawkeyoon, T. Randall Lee
Format:	Journal
Published:	2018
Subjects:	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics
Online Access:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33745141952&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/61512
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Institution:	Chiang Mai University

id	th-cmuir.6653943832-61512
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spelling	th-cmuir.6653943832-615122018-09-11T09:01:41Z The influence of pH on the G-quadruplex binding selectivity of perylene derivatives Wirote Tuntiwechapikul Thanachai Taka Mathilde Béthencourt Luksana Makonkawkeyoon T. Randall Lee Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics Three new perylene derivatives with branched ionizable side chains were synthesized, and their G-quadruplex binding specificities were compared by spectroscopic and electrophoretic analysis with two well-studied G-quadruplex ligands: PIPER and TmPyP4. The value of pH and consequent charge formation and self-aggregation of these perylene derivatives influences not only the type of G-quadruplex formation, but also the G-quadruplex binding selectivity. © 2006 Elsevier Ltd. All rights reserved. 2018-09-11T08:54:27Z 2018-09-11T08:54:27Z 2006-08-01 Journal 0960894X 2-s2.0-33745141952 10.1016/j.bmcl.2006.04.078 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33745141952&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/61512
institution	Chiang Mai University
building	Chiang Mai University Library
country	Thailand
collection	CMU Intellectual Repository
topic	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics
spellingShingle	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics Wirote Tuntiwechapikul Thanachai Taka Mathilde Béthencourt Luksana Makonkawkeyoon T. Randall Lee The influence of pH on the G-quadruplex binding selectivity of perylene derivatives
description	Three new perylene derivatives with branched ionizable side chains were synthesized, and their G-quadruplex binding specificities were compared by spectroscopic and electrophoretic analysis with two well-studied G-quadruplex ligands: PIPER and TmPyP4. The value of pH and consequent charge formation and self-aggregation of these perylene derivatives influences not only the type of G-quadruplex formation, but also the G-quadruplex binding selectivity. © 2006 Elsevier Ltd. All rights reserved.
format	Journal
author	Wirote Tuntiwechapikul Thanachai Taka Mathilde Béthencourt Luksana Makonkawkeyoon T. Randall Lee
author_facet	Wirote Tuntiwechapikul Thanachai Taka Mathilde Béthencourt Luksana Makonkawkeyoon T. Randall Lee
author_sort	Wirote Tuntiwechapikul
title	The influence of pH on the G-quadruplex binding selectivity of perylene derivatives
title_short	The influence of pH on the G-quadruplex binding selectivity of perylene derivatives
title_full	The influence of pH on the G-quadruplex binding selectivity of perylene derivatives
title_fullStr	The influence of pH on the G-quadruplex binding selectivity of perylene derivatives
title_full_unstemmed	The influence of pH on the G-quadruplex binding selectivity of perylene derivatives
title_sort	influence of ph on the g-quadruplex binding selectivity of perylene derivatives
publishDate	2018
url	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33745141952&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/61512
_version_	1681425634604089344

The influence of pH on the G-quadruplex binding selectivity of perylene derivatives

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