The influence of pH on the G-quadruplex binding selectivity of perylene derivatives

• Main Authors: Wirote Tuntiwechapikul, Thanachai Taka, Mathilde Béthencourt, Luksana Makonkawkeyoon, T. Randall Lee
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33745141952&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/61512
• Institution: Chiang Mai University

Three new perylene derivatives with branched ionizable side chains were synthesized, and their G-quadruplex binding specificities were compared by spectroscopic and electrophoretic analysis with two well-studied G-quadruplex ligands: PIPER and TmPyP4. The value of pH and consequent charge formation...