Cadmium induces apoptotic program imbalance and cell cycle inhibitor expression in cultured human astrocytes

• Main Authors: Dusadee Ospondpant, Suttinee Phuagkhaopong, Kran Suknuntha, Kant Sangpairoj, Thitima Kasemsuk, Chutima Srimaroeng, Pornpun Vivithanaporn
• Format: Journal
• Published: 2019
• Subjects: Environmental Science; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85057734636&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/63665
• Institution: Chiang Mai University

© 2018 Elsevier B.V. Cadmium is a highly neurotoxic heavy metal impairing neurogenesis and induces neurodegenerative disorders. Toxic concentrations of cadmium induce astrocytic apoptosis by depleting intracellular glutathione levels, elevating intracellular calcium levels, altering mitochondria mem...