New 1,3,4-thiadiazole Derivatives Endowed with Analgesic and Anti-inflammatory Activities
In the present study, novel different Schiff bases of 2,5-disubstituted-1,3,4-thiadiazole were synthesized. The chemical structures were confirmed by IR, 1H NMR and elemental analysis. All the new compounds were tested in vivo for their analgesic and anti-inflammatory activities. Among them in parti...
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| Main Authors: | , , , , , |
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| Format: | บทความวารสาร |
| Language: | English |
| Published: |
Science Faculty of Chiang Mai University
2019
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| Online Access: | http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=8971 http://cmuir.cmu.ac.th/jspui/handle/6653943832/64082 |
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| Institution: | Chiang Mai University |
| Language: | English |
| Summary: | In the present study, novel different Schiff bases of 2,5-disubstituted-1,3,4-thiadiazole were synthesized. The chemical structures were confirmed by IR, 1H NMR and elemental analysis. All the new compounds were tested in vivo for their analgesic and anti-inflammatory activities. Among them in particular compound 5-(2-Mercaptophenyl)-2-{N-(4-methoxybenzylidene)-4-aminophenyl}-1,3,4-thiadiazole 6f was found to have a superior analgesic and anti-inflammatory profile with low gastric ulceration incidence. |
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