New 1,3,4-thiadiazole Derivatives Endowed with Analgesic and Anti-inflammatory Activities
In the present study, novel different Schiff bases of 2,5-disubstituted-1,3,4-thiadiazole were synthesized. The chemical structures were confirmed by IR, 1H NMR and elemental analysis. All the new compounds were tested in vivo for their analgesic and anti-inflammatory activities. Among them in parti...
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Science Faculty of Chiang Mai University
2019
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| Online Access: | http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=8971 http://cmuir.cmu.ac.th/jspui/handle/6653943832/64082 |
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th-cmuir.6653943832-640822019-05-07T09:59:46Z New 1,3,4-thiadiazole Derivatives Endowed with Analgesic and Anti-inflammatory Activities Ajit Kumar Pandey Pranita P Kashyap Chanchal Deep Kaur Hemant A Sawarkar Hemant J Dhongade Mukesh Kumar Singh In the present study, novel different Schiff bases of 2,5-disubstituted-1,3,4-thiadiazole were synthesized. The chemical structures were confirmed by IR, 1H NMR and elemental analysis. All the new compounds were tested in vivo for their analgesic and anti-inflammatory activities. Among them in particular compound 5-(2-Mercaptophenyl)-2-{N-(4-methoxybenzylidene)-4-aminophenyl}-1,3,4-thiadiazole 6f was found to have a superior analgesic and anti-inflammatory profile with low gastric ulceration incidence. 2019-05-07T09:59:46Z 2019-05-07T09:59:46Z 2018 บทความวารสาร 0125-2526 http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=8971 http://cmuir.cmu.ac.th/jspui/handle/6653943832/64082 Eng Science Faculty of Chiang Mai University |
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Thailand |
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English |
| description |
In the present study, novel different Schiff bases of 2,5-disubstituted-1,3,4-thiadiazole were synthesized. The chemical structures were confirmed by IR, 1H NMR and elemental analysis. All the new compounds were tested in vivo for their analgesic and anti-inflammatory activities. Among them in particular compound 5-(2-Mercaptophenyl)-2-{N-(4-methoxybenzylidene)-4-aminophenyl}-1,3,4-thiadiazole 6f was found to have a superior analgesic and anti-inflammatory profile with low gastric ulceration incidence. |
| format |
บทความวารสาร |
| author |
Ajit Kumar Pandey Pranita P Kashyap Chanchal Deep Kaur Hemant A Sawarkar Hemant J Dhongade Mukesh Kumar Singh |
| spellingShingle |
Ajit Kumar Pandey Pranita P Kashyap Chanchal Deep Kaur Hemant A Sawarkar Hemant J Dhongade Mukesh Kumar Singh New 1,3,4-thiadiazole Derivatives Endowed with Analgesic and Anti-inflammatory Activities |
| author_facet |
Ajit Kumar Pandey Pranita P Kashyap Chanchal Deep Kaur Hemant A Sawarkar Hemant J Dhongade Mukesh Kumar Singh |
| author_sort |
Ajit Kumar Pandey |
| title |
New 1,3,4-thiadiazole Derivatives Endowed with Analgesic and Anti-inflammatory Activities |
| title_short |
New 1,3,4-thiadiazole Derivatives Endowed with Analgesic and Anti-inflammatory Activities |
| title_full |
New 1,3,4-thiadiazole Derivatives Endowed with Analgesic and Anti-inflammatory Activities |
| title_fullStr |
New 1,3,4-thiadiazole Derivatives Endowed with Analgesic and Anti-inflammatory Activities |
| title_full_unstemmed |
New 1,3,4-thiadiazole Derivatives Endowed with Analgesic and Anti-inflammatory Activities |
| title_sort |
new 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities |
| publisher |
Science Faculty of Chiang Mai University |
| publishDate |
2019 |
| url |
http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=8971 http://cmuir.cmu.ac.th/jspui/handle/6653943832/64082 |
| _version_ |
1681426015203622912 |