Analysis of chorismate mutase catalysis by QM/MM modelling of enzyme-catalysed and uncatalysed reactions
Chorismate mutase is at the centre of current controversy about fundamental features of biological catalysts. Some recent studies have proposed that catalysis in this enzyme does not involve transition state (TS) stabilization but instead is due largely to the formation of a reactive conformation of...
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Main Authors: | Claeyssens F., Ranaghan K.E., Lawan N., MacRae S.J., Manby F.R., Harvey J.N., Mulholland A.J. |
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格式: | Article |
語言: | English |
出版: |
2014
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在線閱讀: | http://www.scopus.com/inward/record.url?eid=2-s2.0-79951592576&partnerID=40&md5=2fbf0f31ca5e28cc4081c2cdb4a656b3 http://cmuir.cmu.ac.th/handle/6653943832/6602 |
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